Table 3:

Adverse events in the intention-to-treat population

	ECMO-facilitated resuscitation (n=15)		Standard ACLS treatment (n=15)
	Number of patients with data	Patients	Number of patients with data	Patients
Number of adverse events
Total number of adverse events	15	166	15	47
Patients with more than one event	15	15 (100%)	15	2 (13%)
Unsuccessful resuscitation from refractory cardiac arrest
Death before admission	15	2 (13%)	15	13 (87%)
Circulatory events
Cardiogenic shock	13	12 (92%)	2	2 (100%)
Inotropes or vasopressors in ICU	13	11 (85%)	2	2 (100%)
CNS events
Cerebral oedema	13	3 (23%)	2	1 (50%)
CNS diffuse ischaemia	13	6 (46%)	2	1 (50%)
Seizure activity	13	0	2	0
Cardiopulmonary resuscitation trauma
Retrosternal or intrathoracic bleeding	13	4 (31%)	2	1 (50%)
Rib fractures	13	11 (85%)	2	2 (100%)
Gastrointestinal events
Acute liver failure or injury	13	9 (69%)	2	2 (100%)
Renal events
Acute kidney injury requiring continuous renal replacement therapy or dialysis	13	10 (77%)	2	1 (50%)
Respiratory events
Aspiration pneumonitis or pneumonia	13	12 (92%)	2	2 (100%)
Pulmonary oedema	13	5 (38%)	2	2 (100%)
Unanticipated device-related adverse events
None	13	NA	2	NA
Procedure-related events
Cracked tubing connector replaced	13	1 (8%)	2	NA
Access-site bleeding requiring transfusion of >3 units of PRBC	13	2 (15%)	2	NA
IVC trauma, retroperitoneal bleeding	13	1 (8%)	2	NA

Data are n (%), unless otherwise specified. ACLS=advanced cardiac life support. ECMO=extracorporeal membrane oxygenation. ICU=intensive care unit. NA=not applicable. PRBC=packed red blood cells. IVC=inferior vena cava.