Table 1.
Odds ratios (OR) and 95% confidence intervals (CI) of the genetically predicted lifestyle factors with COVID-19 severe illness
| Lifestyle factor | Number of variants | Severe respiratory COVID-19 | COVID-19 hospitalization | ||
|---|---|---|---|---|---|
| OR (95% CI) | P | OR (95% CI) | P | ||
| Body mass index | 656 | 1.91 (1.55, 2.35) | 7.4 × 10–10 | 1.75 (1.52, 2.01) | 9.0 × 10–15 |
| Lifetime smoking | 126 | 1.84 (1.08, 3.13) | 0.02 | 2.15 (1.52, 3.03) | 1.5 × 10–05 |
| Physical activity | 5 | 0.19 (0.05, 0.74) | 0.02 | 0.44 (0.18, 1.07) | 0.07 |
| Alcohol consumption: all variants | 80 | 1.64 (0.70, 3.81) | 0.25 | 1.57 (0.90, 2.73) | 0.11 |
| Alcohol consumption: rs1229984, rs2532276 removed | 78 | 0.64 (0.25, 1.64) | 0.35 | 1.11 (0.57, 2.17) | 0.76 |
OR and 95% CI were expressed as per standard deviation increase in genetically predicted levels in body mass index, lifetime smoking, accelerometer-measured physical activity and alcohol consumption (log-transformed standard drinks per week)