Table 3.

Comparison of the toxemia model with clinical sepsis

Similarities with Human Disease	Differences with Human Disease
Endotoxin induces shock state in both mice and humans	Humans more sensitive than mice to endotoxin The dose of lipopolysaccharide (LPS) resulting in 50% death (LD50) in mice is approximately 1–25 mg/kg body weight,61–63 whereas an LPS dose of 2–4 ng/kg body weight in humans can inflict severe sickness64,65 Model does not recapitulate the clinical hemodynamic phases Different cytokine responses