TABLE 3.
Sparsified loadings of the common factors that show significant difference between groups in the supervised integrated factor analysis (SIFA)
| rsfMRI | Loading | FA | Loading | MD | Loading | Volume | Loading | ||
|---|---|---|---|---|---|---|---|---|---|
| FEP vs. HC | Factor 1 positive | STG R‐thalamus R | 0.166 | GenuCC | 0.244 | SFOF R | 0.287 | SFO R | 0.378 |
| STG R‐thalamus L | 0.127 | Cingulum R | 0.209 | IO R | 0.142 | AntCR R | 0.101 | ||
| Rectus R‐ITG R | 0.101 | Cingulum L | 0.158 | SS R | 0.084 | SLF R | 0.097 | ||
| MTGpole L‐thalamus R | 0.063 | BodyCC | 0.097 | IO L | 0.063 | SFO L | 0.082 | ||
| Angular R‐thalamus R | 0.043 | MiddleCerebP R | 0.095 | ST R | 0.061 | Rectus R | 0.064 | ||
| MOGL‐ThalamusR | 0.043 | IFOF L | 0.06 | Uncinate L | 0.058 | AntCR L | 0.034 | ||
| SPG R‐thalamus R | 0.028 | Thalamus R | 0.035 | MT R | 0.053 | ||||
| SPG R‐PrCu L | 0.017 | Cingulate L | 0.022 | MT L | 0.04 | ||||
| SPG R‐dorsalACC R | 0.014 | MiddleCerebP L | 0.002 | Fusiform R | 0.004 | ||||
| MTGpole L‐thalamus L | 0.008 | ||||||||
| Factor 1 negative | PoCG L‐SMG R | −0.22 | Uncinate L | −0.174 | BodyCC | −0.294 | IFGtr L | −0.262 | |
| SOG L‐thalamus L | −0.071 | Uncinate R | −0.144 | MFO L | −0.181 | SFG R | −0.208 | ||
| PrCG R‐thalamus L | −0.069 | MFO R | −0.099 | Thalamus L | −0.127 | IFGop R | −0.142 | ||
| PrCG L‐PrCu L | −0.051 | GP R | −0.095 | CP L | −0.115 | IFGtr R | −0.128 | ||
| SPG L‐thalamus R | −0.035 | LFO L | −0.082 | Thalamus R | −0.114 | LFOG L | −0.108 | ||
| PrCG L‐SMG L | −0.003 | PrC L | −0.062 | GenuCC | −0.078 | SPG R | −0.069 | ||
| PostCR L | −0.025 | SpleniumCC | −0.056 | IFGorb L | −0.056 | ||||
| PostCR R | −0.001 | MFO R | −0.054 | SFG L | −0.028 | ||||
| CP R | −0.018 | MOG L | −0.005 | ||||||
| MTG R | −0.004 | ||||||||
| Factor 2 positive | PCC R‐thalamus R | 0.031 | SupCR R | 0.311 | RetrolenticularIC R | 0.114 | SMG R | 0.275 | |
| MFOG L‐insula L | 0.027 | SupCR L | 0.196 | SLF R | 0.088 | SMG L | 0.174 | ||
| PrCG R‐PrCu L | 0.022 | Insula R | 0.095 | Putamen L | 0.085 | MFGdpfc L | 0.074 | ||
| PrCG R‐thalamus L | 0.012 | IF L | 0.09 | IT R | 0.055 | IFGtr R | 0.056 | ||
| MFOG R‐insula L | 0.002 | PostLimbIC L | 0.069 | PostLimbIC L | 0.049 | Put L | 0.049 | ||
| MTGpole L‐thalamus L | 0 | SLF R | 0.068 | Fusiform R | 0.014 | PoCG L | 0.024 | ||
| IF R | 0.061 | PrCu R | 0.003 | ||||||
| Insula L | 0.051 | MFO L | 0.002 | ||||||
| Fusiform L | 0.046 | ||||||||
| Caudate R | 0.01 | ||||||||
| Cingulate R | 0.073 | ||||||||
| Factor 2 negative | SPG R‐dorsalACC L | −0.373 | AntLimbIC L | −0.129 | Insula L | −0.4 | SFO L | −0.24 | |
| STGpole R‐put R | −0.215 | SpleniumCC | −0.118 | Caudate R | −0.303 | SupCR L | −0.102 | ||
| Lingual R‐thalamus L | −0.208 | SO R | −0.096 | Insula R | −0.27 | Cuneus R | −0.04 | ||
| SOG R‐lingual R | −0.052 | IO L | −0.054 | MiddleCerebP L | −0.03 | PrCu L | −0.034 | ||
| IOGR‐ThalamusR | −0.035 | Total white matter | −0.023 | MTGpole L | −0.028 | ||||
| PrCu L‐MTG R | −0.03 | Uncinate R | −0.008 | PostCR L | −0.021 | ||||
| LFOGR‐InsulaR | −0.03 | SOG R | −0.01 | ||||||
| LFOGR‐InsulaL | −0.018 | ||||||||
| IOGR‐ThalamusL | −0.009 | ||||||||
| SOGL‐ThalamusL | −0.004 | ||||||||
| S‐FEP vs. HC | Factor 2 positive | STG pole R‐put R | 0.163 | BodyCC | 0.07 | SFOF R | 0.253 | SOG R | 0.215 |
| Rectus R‐ITG R | 0.154 | Cingulum R | 0.069 | GP R | 0.244 | Cu R | 0.161 | ||
| STG R‐thalamus R | 0.119 | Cingulum_L | 0.044 | MT L | 0.195 | PTR R | 0.111 | ||
| SPG R‐dorsal ACC L | 0.114 | MiddleCerebP R | 0.04 | Insula L | 0.107 | SOG L | 0.089 | ||
| SPG R‐dorsal ACC R | 0.036 | IFOF L | 0.021 | ST L | 0.106 | SFO L | 0.08 | ||
| Lingual R‐thalamus L | 0.028 | IFOF R | 0.001 | MT R | 0.105 | MFG R | 0.075 | ||
| MOG L‐thalamus L | 0.011 | ST R | 0.087 | MTGpole L | 0.052 | ||||
| PoCG R‐IOG R | 0.009 | SS R | 0.072 | SupCR L | 0.042 | ||||
| MFOG L‐STG pole R | 0.001 | Cu L | 0.034 | ||||||
| Lingual L | 0.021 | ||||||||
| PostCR L | 0.014 | ||||||||
| Factor 2 negative | MFOG L‐insula L | −0.271 | LFO L | −0.266 | PostLimbIC L | −0.342 | SS L | ||
| FusiformG R‐thalamus R | −0.141 | LFO R | −0.189 | Thalamus L | −0.179 | SFG pole L | −0.154 | ||
| MFOG R‐insula L | −0.137 | Uncinate L | −0.181 | MFO L | −0.123 | MTG R | −0.018 | ||
| PrCG R‐thalamus L | −0.06 | MFO R | −0.157 | Caudate L | −0.123 | LFOG L | −0.115 | ||
| SOG L‐thalamus L | −0.058 | SupCR L | −0.142 | SF L | −0.048 | Insula R | −0.087 | ||
| MFOG R‐insula R | −0.056 | PostCR L | −0.098 | Putamen L | −0.031 | MOG L | −0.083 | ||
| PoCG L‐SPG R | −0.044 | RetrolenticularIC L | −0.056 | BodyCC | −0.002 | SFG R | −0.076 | ||
| SOG R‐cu L | −0.031 | SF R | −0.05 | SMG R | −0.061 | ||||
| PoCG L‐SMG L | −0.022 | Rectus R | −0.047 | IFG L | −0.013 | ||||
| PostLimbIC L | −0.009 | SFG pole R | −0.011 | ||||||
| Fusiform L | −0.003 | ||||||||
| M‐FEP vs. HC | Factor 1 positive | MTG R‐thalamus L | 0.21 | PostCR R | 0.145 | EC L | 0.166 | Put R | 0.274 |
| PoCG R‐thalamus L | 0.078 | PostThalamicRad R | 0.106 | Uncinate L | 0.125 | IFtr R | 0.243 | ||
| PrCG L‐SPG L | 0.051 | RetrolenticularIC R | 0.105 | IFOF L | 0.11 | Put L | 0.217 | ||
| PoCG L‐thalamus L | 0.023 | PostCR L | 0.049 | Putamen L | 0.101 | IFtr L | 0.211 | ||
| PrCG R‐SPG L | 0.014 | IF L | 0.045 | AntLimbIC L | 0.074 | SFG R | 0.1 | ||
| PoCG R‐thalamus R | 0.009 | SS L | 0.037 | InfFrontal L | 0.049 | Caudate L | 0.043 | ||
| Fusiform L | 0.025 | SupCR L | 0.035 | IFop R | 0.038 | ||||
| GP L | 0.002 | MTGpole R | 0.034 | ||||||
| SFG L | 0.005 | ||||||||
| BodyCC | 0.004 | ||||||||
| SFGpole R | 0.002 | ||||||||
| Factor 1 negative | FusiformG R‐thalamus R | −0.137 | GenuCC | −0.293 | IO R | −0.267 | SFO R | −0.443 | |
| SPG R‐thalamus L | −0.111 | AntLimbIC L | −0.17 | MO R | −0.173 | SLF L | −0.1 | ||
| PoCG L‐SPG L | −0.101 | BodyCC | −0.165 | ST R | −0.112 | SFO L | −0.044 | ||
| IOG R‐cu L | −0.085 | AntCR L | −0.14 | Cuneus R | −0.092 | AntCR R | −0.018 | ||
| SOG R‐cu L | −0.08 | AntLimbIC R | −0.064 | Fusiform R | −0.082 | SLF R | −0.016 | ||
| SOG L‐thalamus L | −0.079 | Cinglum R | −0.047 | Lingual R | −0.05 | ACR L | −0.012 | ||
| MTG L‐thalamus R | −0.074 | CP R | −0.008 | PostThalamicRad R | −0.008 | PoCG L | −0.005 | ||
| PoCG L‐SPG R | −0.069 | IFOF L | −0.003 | ||||||
| MFG R‐PCC L | −0.034 | ||||||||
| STG R‐thalamus R | −0.034 | ||||||||
| STGpole R‐put R | −0.021 |
Abbreviations: Cortex*: SFG, MFG, IFG: superior, middle, inferior frontal gyri; IFGtr, IFGop, IFGorb: pars triangularis, opercularis, and orbitalis of IFG, MFGdpfc: dorsal prefrontal cortex; MFOG, LFOG: medium and lateral frontorbital gyri; STG, MTG, ITG: superior, middle, and inferior temporal gyri; SOG, MOG, IOG: superior, middle, and inferior occipital gyri; PrCG, PoCG: pre and post central gyri; PCC, ACC: posterior and anterior cingulate cortex; SMG: supramarginal gyrus; SPG: superior parietal gyrus; PrCu: precuneus gyrus. * For the analysis of FA and MD, the ROIs (no “G”) represent the white matter beneath the cortex. Deep white matter: IFOF: inferior frontoccipital fasciculus; ILF, SFL: inferior and superior longitudinal fasciculus; IC, EC: internal and external capsule; CP, CerebP: cerebral and cerebellar peduncle; CC: corpus callosum; CR: corona radiata, SS: sagittal stratum. Put: Putamen, GP: Globus Pallidus. Post, Ant, Sup, Inf: posterior, anterior, superior, inferior; L, R: left, right.