TABLE 4.

Diagnostic indices

	AUC	95% CI	CUT‐OFF	SENS (%)	SPEC (%)	ACC (%)	PPV (%)	NPV (%)	J	LR−	LR+
Discovery cohort (Oxford)
MD	0.862	0.747–0.963	1.0979	79	83	81	83	79	0.617	0.25	4.5
AngleR	0.887	0.791–0.983	0.98096	88	87	87	88	87	0.744	0.14	6.7
PerpPD	0.850	0.733–0.967	0.63542	71	91	81	89	75	0.621	0.31	8.1
ParlPD	0.792	0.655–0.930	0.41828	63	91	77	88	70	0.538	0.41	7.2
GM fr	0.816	0.695–0.937	0.27642	67	91	79	89	72	0.579	0.36	7.6
Test cohort (Rome)
MD	0.858	0.750–0.965	1.09798	90	78	85	84	86	0.679	0.13	4.12
AngleR	0.931	0.866–0.997	0.98313	86	96	90	96	85	0.815	0.14	20.6
PerpPD	0.903	0.812–0.993	0.65594	81	92	87	91	83	0.730	0.21	10.5
ParlPD	0.798	0.668–0.928	0.43162	90	65	79	76	83	0.548	0.16	2.6
GM fr	0.860	0.772–0.966	0.24313	86	74	81	81	81	0.601	0.19	3.3
ATN cohort (ADNI 3)
MD	0.629	0.461–0.797	0.95613	68	80	74	77	71	0.48	0.40	3.4
AngleR	0.896	0.808–0.984	0.96884	96	72	84	77	95	0.68	0.06	3.4
PerpPD	0.666	0.504–0.827	0.52954	64	84	74	80	70	0.48	0.43	4
ParlPD	0.597	0.428–0.766	0.36071	60	76	68	71	65	0.44	0.52	2.5
GM fr	0.798	0.651–0.945	0.27578	64	88	76	84	71	0.52	0.41	5.3
AV45 PET	—	—	1.11	88	64	74	64	88	0.58	0.30	4.5
AV1451 PET	—	—	1.33	55	96	78	91	74	0.51	0.46	13.33

Note: The Table shows the accuracy indices for each studied measure. The bold values represent the best diagnostic performance. AngleR values are expressed in radians (Θrad); MD, PerpPD, and ParlPD values are expressed in (×10⁻³ mm²/s).

Abbreviations: 95% CI, 95% confidence interval; ACC, Accuracy; AUC, area under the curve; GMfr, Grey matter fraction; J, Youden's J statistic; LR+, LR−, likelihood ratio positive and negative; MD, mean diffusivity; NPV, negative predictive values; PPV, positive predictive values; SENS, sensitivity; SPEC, specificity.