TABLE 1.
Participant characteristics
| HC (n = 36) | All patients (n = 35) | RRMS (n = 14, 40%) | PMS (n = 21, 60%) | |
|---|---|---|---|---|
| Age, y, mean (SD) | 45.86 (12.45) | 46.2 (11.62) | 37.14 (9.4) | 52.23 (8.8) |
| Sex (F/M) | 20/16 | 21/14 | 9/5 | 12/9 |
| Treatment (first line/second line/non‐validated therapies) | 9/5/0 | 2/3/2 | ||
| Disease duration, y, median (range) | N/A | 13 (0.5 to 35) | 8 (0.5 to 28) | 13 (2 to 35) |
| Baseline EDSS, median (range) | 4 (1 to 6.0) | 2 (1 to 5.5) | 4.5 (3 to 6.0) | |
| Motor score, mean (SD) | 0.03 (0.72) | −2.32 (2.24) | −0.51 (1.21) | −3.39 (2) |
| Cognitive score, mean (SD) | 0.04 (0.75) | −1.45 (1.74) | −0.22 (0.9) | −2.28 (1.68) |
| Scanner 1/scanner 2 | 11/25 | 25/10 | 10/4 | 15/6 |
| Volumetric data, %, mean (SD) | ||||
| Gray matter fraction (GMF) | 52.76 (1.99) | 49.55 (3.02) a | ||
| Lesion fraction | N/A | 1.82 (1.4) | ||
| Median MPM values summarized over the whole tissue class, mean (SD) | ||||
| MT (p.u) | ||||
| CGM | 0.82 (0.09) | 0.69 (0.27) a | ||
| DGM | 0.98 (1.13) | 0.87 (0.11) a | ||
| R1 (Hz) | ||||
| CGM | 0.64 (0.02) | 0.62 (0.02) a | ||
| DGM | 0.77 (0.06) | 0.75 (0.05) b | ||
| R2* (Hz) | ||||
| CGM | 16.62 (1.02) | 15.35 (1.16) a | ||
| DGM | 22.04 (3.10) | 21.71 (2.9) c | ||
Note: ANOVA testing for differences between HC and MS patients.
Abbreviations: CGM, cortical gray matter; DGM, deep gray matter; GMF, gray matter fraction (GM/TIV volume); HC, healthy controls; LF, lesion fraction (lesion/TIV volume); PMS, progressive multiple sclerosis (primary and secondary PMS); RRMS, relapsing–remitting multiple sclerosis; TIV, total intracranial volume.
a
Differences statistically different at p < .0001.
b
Differences not statistically different, p = .06.
c
Differences not statistically different, p = .68.