TABLE 1.

Characteristics of the study cohort

Demographics	Study cohort (N = 442)
MMSE mean (SD); range	28.2 (1.6); 22–30
Age, mean (SD); range	65.4 (8.8); 50–85
Male (%)	246 (55)
Education years (SD); range	10.8 (3.5); 5–17
Neuroimaging
White matter lesion volume (ml) median a	3.4
Lacunar infarct (%)	110 (25)
Microbleeds (%)	74 (17)

Note: MMSE, maximum score is 30, cutoff of cognitive impairment is <24.

Abbreviations: ICV, intracranial volume; MMSE, Mini Mental State Examination; WMH, white matter hyperintensity.

^a Corrected for ICV formula: $\frac{\mathrm{raw}\mathrm{WMH}\text{volume}}{\mathrm{raw}\mathrm{ICV}}\times \text{mean}\mathrm{ICV}\text{of group}\mathrm{N}.$