TABLE 1.
Mean simulation values for all manipulated factors for single anatomical target simulations: probability of obtaining a positive result, as a percentage of trials where significant voxels were detected (positive result [%]), average displacement error across all distance‐based metrics (displacement [mm]), Dice index, and OSK distribution statistic (OSK statistic: −1 worst to +1 best)
| LSM method | ULSM T‐max | ULSM T‐nu = 125 | ULSM T‐0.0001 | ULSM T‐0.001 | ULSM T‐0.01 | SVR | PLS | ICA‐L1 | ICA‐L2 | LPCA‐L1 | LPCA‐L2 | SVD‐L1 | SVD‐L2 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Positive result (%) | 98.4 | — a | 98.5 | 98.8 | 98.1 | 97.2 | 93.2 | 93.9 | 95.0 | 95.8 | 96.4 | 93.9 | 93.3 |
| Displacement (mm) | 6.1 | 6.7 | 6.4 | 6.9 | 7.6 | 6.0 | 12.9 | 12.3 | 13.1 | 12.3 | 11.4 | 8.3 | 8.0 |
| Dice index | 0.12 | 0.08 | 0.09 | 0.07 | 0.05 | 0.14 | 0.03 | 0.05 | 0.04 | 0.03 | 0.03 | 0.04 | 0.05 |
| OSK statistic | 0.43 | 0.56 | 0.52 | 0.60 | 0.68 | 0.29 | 0.54 | 0.20 | 0.35 | 0.59 | 0.61 | 0.65 | 0.66 |
| Sample size | 32 | 48 | 64 | 80 | 96 | 112 | 128 | 208 b |
|---|---|---|---|---|---|---|---|---|
| Positive result (%) | 82.9 | 94 | 98.4 | 99.4 | 99.8 | 99.9 | 99.9 | 100 |
| Displacement (mm) | 10.2 | 9.4 | 9.0 | 8.9 | 8.8 | 8.7 | 8.7 | 9.8 |
| Dice index | 0.10 | 0.08 | 0.07 | 0.06 | 0.05 | 0.05 | 0.05 | 0.03 |
| OSK statistic | −0.10 | 0.36 | 0.50 | 0.57 | 0.63 | 0.67 | 0.71 | 0.74 |
| Behavioral noise level | 0 | 0.38 | 0.77 |
|---|---|---|---|
| Positive result (%) | 99.2 | 97.9 | 91.9 |
| Displacement (mm) | 8.9 | 9.1 | 9.2 |
| Dice index | 0.05 | 0.06 | 0.08 |
| OSK statistic | 0.62 | 0.55 | 0.37 |
| Mask smoothness | 0 mm | 4 mm |
|---|---|---|
| Positive result (%) | 96.3 | 96.4 |
| Displacement (mm) | 9.2 | 8.9 |
| Dice index | 0.06 | 0.05 |
| OSK statistic | 0.49 | 0.54 |
| Number of parcels | 16 | 30 |
|---|---|---|
| Positive result (%) | 96.4 | 96.3 |
| Displacement (mm) | 9.4 | 8.9 |
| Dice index | 0.08 | 0.05 |
| OSK statistic | 0.38 | 0.59 |
| Anatomical parcels | Mean | SD | Max | Min | Quart 1 | Quart 3 |
|---|---|---|---|---|---|---|
| Positive result (%) | 96.3 | 2.7 | 99.6 | 88 | 95.3 | 98.3 |
| Displacement (mm) | 9.1 | 2.6 | 15.0 | 5.0 | 6.3 | 10.7 |
| Dice index | 0.06 | 0.04 | 0.14 | 0.01 | 0.03 | 0.09 |
| OSK statistic | 0.51 | 0.27 | 0.82 | −0.37 | 0.38 | 0.70 |
Abbreviations: ICA, independent component analysis; LPCA, logistic principal component analysis; LSM, lesion symptom mapping; MLSM, multivariate lesion‐symptom mapping; OSK, one‐sided Kuiper; PLS, partial least squares; ULSM, univariate lesion‐symptom mapping; SVD, singular value decomposition; SVR, support vector regression.
Probability of obtaining a positive result not calculated due to a technical error.
Indices provided for informational purposes only and not included in the statistical analyses.