Skip to main content
. 2021 Jan 20;7:599096. doi: 10.3389/fcvm.2020.599096

Table 4.

Overall performance of cardiac biomarkers for predicting in-hospital mortality in overall study population, cardiac, and non-cardiac patients according to ROC curves.

Biomarkers AUC (95% CI) p value Cut-off Sensitivity, % Specificity, %
All included patients (n = 1,023) Hs-TnI 0.822 (0.761–0.882) <0.001 7.85 pg/mL 75.0 76.3
CK-MB 0.763 (0.689–0.838) <0.001 1.15 ng/mL 70.0 75.3
Myo 0.875 (0.822–0.928) <0.001 80.55 ng/mL 83.3 85.6
NT-proBNP 0.881 (0.841–0.920) <0.001 301.5 pg/mL 85.0 80.6
Non-cardiac patients (n = 897) Hs-TnI 0.842 (0.774–0.911) <0.001 22.95 pg/mL 60.5 94.8
CK-MB 0.837 (0.761–0.913) <0.001 1.15 ng/mL 79.1 78.5
Myo 0.895 (0.837–0.953) <0.001 80.55 ng/mL 86.0 86.7
NT-proBNP 0.888 (0.839–0.936) <0.001 266.0 pg/mL 83.7 82.2
Cardiac patients (n = 126) Hs-TnI 0.664 (0.528–0.801) 0.030 8.65 pg/mL 82.4 55.1
CK-MB 0.532 (0.366–0.697) 0.674 ns - -
Myo 0.778 (0.655–0.902) <0.001 82.10 ng/mL 76.5 78.0
NT-proBNP 0.753 (0.659–0.847) 0.001 352.5 pg/mL 94.1 56.9

ns indicates non-significant.

AUC, area under the ROC curves; Hs-TnI, High sensitivity troponin-I; CK-MB, creatine kinase-MB; Myo, myoglobin; NT-proBNP, N terminal pro B type natriuretic peptide.