Table 4.
Biomarkers | AUC (95% CI) | p value | Cut-off | Sensitivity, % | Specificity, % | |
---|---|---|---|---|---|---|
All included patients (n = 1,023) | Hs-TnI | 0.822 (0.761–0.882) | <0.001 | 7.85 pg/mL | 75.0 | 76.3 |
CK-MB | 0.763 (0.689–0.838) | <0.001 | 1.15 ng/mL | 70.0 | 75.3 | |
Myo | 0.875 (0.822–0.928) | <0.001 | 80.55 ng/mL | 83.3 | 85.6 | |
NT-proBNP | 0.881 (0.841–0.920) | <0.001 | 301.5 pg/mL | 85.0 | 80.6 | |
Non-cardiac patients (n = 897) | Hs-TnI | 0.842 (0.774–0.911) | <0.001 | 22.95 pg/mL | 60.5 | 94.8 |
CK-MB | 0.837 (0.761–0.913) | <0.001 | 1.15 ng/mL | 79.1 | 78.5 | |
Myo | 0.895 (0.837–0.953) | <0.001 | 80.55 ng/mL | 86.0 | 86.7 | |
NT-proBNP | 0.888 (0.839–0.936) | <0.001 | 266.0 pg/mL | 83.7 | 82.2 | |
Cardiac patients (n = 126) | Hs-TnI | 0.664 (0.528–0.801) | 0.030 | 8.65 pg/mL | 82.4 | 55.1 |
CK-MB | 0.532 (0.366–0.697) | 0.674 | ns | - | - | |
Myo | 0.778 (0.655–0.902) | <0.001 | 82.10 ng/mL | 76.5 | 78.0 | |
NT-proBNP | 0.753 (0.659–0.847) | 0.001 | 352.5 pg/mL | 94.1 | 56.9 |
ns indicates non-significant.
AUC, area under the ROC curves; Hs-TnI, High sensitivity troponin-I; CK-MB, creatine kinase-MB; Myo, myoglobin; NT-proBNP, N terminal pro B type natriuretic peptide.