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. Author manuscript; available in PMC: 2022 Feb 15.
Published in final edited form as: Bioorg Med Chem. 2021 Jan 8;32:116000. doi: 10.1016/j.bmc.2021.116000

Figure 1.

Figure 1.

“Positional switch” hypothesis indicating no interaction of the CH2OH group at position 5 in the thiazole ring in the x-ray structure of NBD-14010 bound to HIV-1 gp120. When the CH2OH was switched to position 4 in the thiazole ring in NBD-14189, it forms H-bond (indicated by violet arrows using a glide docking pose) with Met426 and Gly43125.