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. 2021 Jan 26;21(3):234. doi: 10.3892/ol.2021.12495

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Copyright: © Liu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — PUMA overexpression regulates the expression of proteins associated with the epithelial-mesenchymal transition and apoptosis. (A) The protein levels of E-cadherin were upregulated, whereas the levels of vimentin were downregulated in the GBC-SD and EHGB-1 OE groups compared with those in the corresponding NC groups. (B) The protein expression levels of Bax were upregulated, whereas the expression levels of Bcl-2 were downregulated in the GBC-SD and EHGB-1 OE groups compared with those in the NC groups. *P<0.05 and **P<0.01. PUMA, p53-upregulated modulator of apoptosis; NC, negative control; OE, PUMA overexpression.