Figure 2.

Differential changes in chromatin accessibility depending on p53 status are associate with distinct gene expression profiles in response to 5-FU. (A) Differentially expressed genes (DEGs) that exhibited greater than two-fold changes with an adjusted P-value of less than 0.05 are denoted in TP53-WT and TP53-KO cells based on the association with 5-FU-induced chromatin accessibility. (B) Volcano plot showing DEGs associated with 5-FU-induced DARs in TP53-WT (left) and TP53-KO (right) cells. (C) and (D) Pathway enrichment analysis for the genes that showed both higher mRNA expression and greater chromatin accessibility upon 5-FU treatment for 24 h in TP53-WT cells (C) or TP53-KO cells (D). TP53-WT, TP53-wild-type; TP53-KO, TP53-knockout.