Table II.
Cox regression analyses of PIGC mRNA level and OS.
| Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|
| Parameter | HR (95% CI) | P-value | HR (95% CI) | P-value |
| Age, years | 1.152 (0.795–1.67) | 0.455 | – | – |
| ≤55 | ||||
| >55 | ||||
| Sex | 0.816 (0.573–1.163) | 0.260 | – | – |
| Male | ||||
| Female | ||||
| AFP level | 1.056 (0.646–1.727) | 0.828 | – | – |
| Normal | ||||
| High | ||||
| Hepatitis | 0.562 (0.37–0.816) | 0.007a | 0.665 (0.411–1.075) | 0.096 |
| No | ||||
| Yes | ||||
| Drinking | 1.026 (0.704–1.479) | 0.892 | – | – |
| No | ||||
| Yes | ||||
| T stage | 2.489 (1.75–3.54) | <0.0001a | 1.375 (0.396–4.778) | 0.616 |
| T1+T2 | ||||
| T3+T4 | ||||
| N stage | 1.152 (1.049–2.179) | 0.027a | 1.14 (0.663–1.961) | 0.635 |
| N0 | ||||
| N1+NX | ||||
| M stage | 1.563 (1.0792.264) | 0.018a | 1.686 (0.972–2.926) | 0.063 |
| M0 | ||||
| M1+MX | ||||
| G stage | 1.004 (0.772–1.306) | 0.977 | – | – |
| G1+G2 | ||||
| G3+G4 | ||||
| TNM stage | 2.488 (1.689–3.548) | <0.0001a | 1.74 (0.506–5.985) | 0.380 |
| I+II | ||||
| III+IV | ||||
| PIGC mRNA | 1.654 (1.166–2.347) | 0.005a | 2.203 (1.476–3.287) | <0.0001a |
| Low | ||||
| High | ||||
a
P<0.05. HCC, hepatocellular carcinoma; PIGC, phosphatidylinositol glycan anchor biosynthesis class C; TNM, tumor node metastasis; AFP, α-feroprotein; OS, overall survival; HR, hazard ratio; CI, confidence interval; G, grade.