Table III.
Cox regression analysis of PIGC mRNA level and DFS.
| Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|
| Parameter | HR (95% CI) | P-value | HR (95% CI) | P-value |
| Age, years | 0.966 (0.707–1.321) | 0.828 | – | – |
| ≤55 | ||||
| >55 | ||||
| Sex | 0.885 (0.645–1.124) | 0.45 | – | – |
| Male | ||||
| Female | ||||
| AFP level | 1.108 (0.734–1.673) | 0.625 | – | – |
| Normal | ||||
| High | ||||
| Hepatitis | 0.889 (0.643–1.228) | 0.475 | – | – |
| No | ||||
| Yes | ||||
| Drinking | 1.011 (0.732–1.395) | 0.948 | – | – |
| No | ||||
| Yes | ||||
| T stage | 2.270 (1.643–3.135) | <0.001a | 1.088 (0.432–2.738) | 0.857 |
| T1+T2 | ||||
| T3+T4 | ||||
| N stage | 1.249 (0.904–1.724) | 0.178 | – | – |
| N0 | ||||
| N1+NX | ||||
| M stage | 1.151 (0.826–1.602) | 0.406 | – | – |
| M0 | ||||
| M1+MX | ||||
| G stage | 1.105 (0.811–1.507) | 0.526 | – | – |
| G1+G2 | ||||
| G3+G4 | ||||
| TNM stage | 2.354 (1.692–3.275) | <0.001a | 2.156 (0.874–5.317) | 0.095 |
| I+II | ||||
| III+IV | ||||
| PIGC mRNA | 1.493 (1.107–2.012) | 0.009a | 1.525 (1.114–2.087) | 0.008a |
| Low | ||||
| High | ||||
a
P<0.05. HCC, hepatocellular carcinoma; PIGC, phosphatidylinositol glycan anchor biosynthesis class C; TNM, tumor node metastasis; AFP, α-feroprotein; DFS, disease-free survival; HR, hazard ratio; CI, confidence interval; G, grade.