Table 2.
Relationships between CYP2D6 genotype and clinical outcomes
| Total study population (n = 76) | |||||
|---|---|---|---|---|---|
| CYP2D6*10 | CYP2D6*2 | CYP2D6*65 | Statistics | P | |
| PANSS0 - week 4 | 19.0 (12.0, 29.0) | 24.0 (13.0, 21.0) | 10.0 (7.5, 20.8) | 5.328 | 0.070 |
| PANSS0 - week 8 | 27.5 (19.0, 33.5) | 34.5 (31.0, 39.5) | 17.0 (13.0, 27.0) | 3.850 | 0.027 |
| BPRS0 – week 4 | 12.0 (8.0, 15.0) | 12.0 (11.0, 13.0) | 11.5 (6.3, 13.0) | 1.059 | 0.589 |
| BPRS0 - week 8 | 16.0 (13.0, 18.5) | 15.0 (14.0, 18.0) | 14.0(7.0, 17.0) | 1.959 | 0.376 |
| CGI-S0 - week 4 | 1.0 (1.0, 2.0) | 2.0 (1.0, 2.0) | 1.0 (1.0, 1.0) | 2.853 | 0.240 |
| CGI-S0 – week 8 | 2.0 (2.0, 3.0) | 3.0 (2.0, 4.0) | 2.0 (2.0, 3.0) | 1.701 | 0.427 |
| CGI-I2 – week 4 | 0.0 (0.0, 1.0) | 0.0 (0.0, 0.0) | 1.0 (0.0, 1.0) | 2.523 | 0.283 |
| CGI-I2 – week 8 | 1.0 (0.0, 1.0) | 1.0 (0.0, 2.0) | 1.0 (0.0, 1.5) | 1.249 | 0.536 |
Data are presented as median (interquartile range)
PANSS0 - week 4 represents the change of PANSS score from 0 to 4 weeks
Abbreviations: BPRS Brief Psychiatric Rating Scale, CGI Clinical Global Impression, CGI-S Clinical Global Impression Severity, CGI-I Clinical Global Impression Improvement, PANSS Positive and Negative Syndrome Scale