Table 5.
Adverse effects among different single-nucleotide polymorphisms
| C100T | C2851T | G4181C | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| C/C | C/T | T/T | Statistics | P | C/C | C/T | Statistics | P | C/C | C/G | Statistics | P | |
| Weight change from week 0 to 4 | 2.3(0.0, 4.3) | 2.0(− 0.8, 4.0) | 1.0(− 1.0, 2.5) | 3.238 | 0.198 | − 1.0(− 3.0, 1.0) | −4.0(−7.6, − 0.3) | −3.091 | 0.008 | −1.3(− 3.0, 0.4) | −1.5(− 3.8, 1.0) | − 0.163 | 0.871 |
| Weight change from week 0 to 8 | − 3.0(− 4.4, − 0.5) | 0.0(−5.0, 0.6) | − 1.0(−2.6, 1.2) | 3.487 | 0.175 | − 1.0(− 4.0, 1.0) | −1.5(− 4.0, 0.0) | − 0.533 | 0.594 | − 1.0(− 4.0, 1.3) | 0.0(−5.0, 0.0) | − 0.510 | 0.610 |
| BMI change from week 0 to 8 | − 1.1(− 1.8, − 0.2) | 0.0(−1.7, 0.2) | − 0.4(− 1.0, 0.4) | 4.010 | 0.135 | − 0.4(− 1.6, 0.3) | (−1.6, 0.0) | − 0.680 | 0.496 | − 0.4(− 1.6, 0.4) | 0.0(− 1.7, 0.0) | − 0.469 | 0.639 |
| GLU change from week 0 to 4 | −0.1(− 0.4, 0.5) | −0.3(− 1.1, 0.2) | −0.5(− 1.3, 0.1) | 2.776 | 0.250 | − 0.3(− 0.9, 0.2) | − 0.4(− 1.2, − 0.1) | − 0.673 | 0.501 | −0.6(− 1.2,-0.1) | − 0.1(− 0.5, 0.4) | −2.401 | 0.016 |
| GLU change from week 0 to 8 | −0.4(− 0.9, − 0.3) | −0.4(− 0.8, 0.6) | −0.2(− 0.7, 0.2) | 0.106 | 0.899 | − 0.2(− 0.8, 0.3) | −0.4(− 0.8, − 0.2) | 0.447 | 0.847 | −0.4(− 0.7, 0.1) | − 0.3(− 0.9, 0.6) | 0.095 | 0.870 |
| TG change from week 0 to 4 | 0.5(− 0.1, 1.7) | 0.0(− 0.3, 0.5) | 0.0(− 0.3, 0.4) | 4.156 | 0.125 | 0.1(− 0.2, 0.6) | − 0.2(− 0.5, 0.5) | −1.497 | 0.134 | −0.1(− 0.4, 0.4) | 0.4(0.0, 0.9) | − 3.206 | 0.001 |
| TG change from week 0 to 8 | 0.3(−0.2, 1.3) | − 0.1(− 0.4, 0.3) | 0.0(− 0.2, 0.3) | 2.879 | 0.237 | 0.1(− 0.3, 0.4) | 0.0(− 0.5, 0.5) | −0.030 | 0.976 | 0.1(−0.5, 0.4) | 0.1(− 0.2, 0.4) | −0.824 | 0.410 |
| CHO change from week 0 to 4 | −0.1(− 1.0, 1.1) | − 0.4(− 0.9, 0.3) | −0.3(− 0.8, 0.0) | 2.813 | 0.067 | − 0.2(− 0.8, 0.3) | −0.4(− 1.0, 0.0) | 0.411 | 0.105 | − 0.3(− 1.0, 0.1) | − 0.2(− 0.6, 0.4) | 0.097 | 0.053 |
| CHO change from week 0 to 8 | −0.3(− 1.2, 0.5) | − 0.5(− 1.0, 0.3) | 0.0(− 0.9, 0.4) | 0.448 | 0.641 | −0.4(− 0.9, 0.4) | −0.4(− 1.5, 0.5) | 6.350 | 0.309 | − 0.6(− 1.0, 0.4) | − 0.3(− 0.7, 0.3) | − 0.901 | 0.346 |
| LDL change from week 0 to 4 | 0.2(−0.5, 0.8) | − 0.1(− 0.4, 0.3) | −0.1(− 0.5, 0.2) | 2.430 | 0.095 | 0.0(− 0.5, 0.4) | 0.0(− 0.3, 0.2) | 0.316 | 0.413 | − 0.2(− 0.5, 0.2) | 0.0(− 0.4, 0.4) | 0.009 | 0.069 |
| LDL change from week 0 to 8 | 0.1(− 0.7, 0.8) | −0.4(− 0.6, 0.2) | −0.1(− 0.5, 0.5) | 0.947 | 0.393 | − 0.2(− 0.6, 0.4) | −0.1(− 0.7, 0.3) | 0.997 | 0.708 | − 0.2(− 0.7, 0.3) | 0.0(− 0.6, 0.4) | − 1.243 | 0.214 |
| HDL change from week 0 to 4 | −0.1(− 0.2, 0.1) | −0.1(− 0.2, 0.0) | −0.1(− 0.3, 0.1) | 0.227 | 0.839 | − 0.1(− 0.2, 0.1) | −0.2(− 0.3, 0.0) | −2.073 | 0.038 | −0.1(− 0.2, 0.0) | 0.0(− 0.2, 0.0) | 3.847 | 0.939 |
| HDL change from week 0 to 8 | −0.2(− 0.3, 0.0) | −0.1(− 0.3, 0.0) | −0.1(− 0.2, 0.1) | 1.129 | 0.569 | − 0.1(− 0.2, 0.1) | −0.2(− 0.4, 0.0) | 4.061 | 0.035 | 0.0(− 0.2, 0.1) | −0.1(− 0.3, 0.0) | − 1.089 | 0.341 |
| PRL change from week 0 to 4 | −56.6(− 117.3, − 10.5) | −42.5(− 98.8, − 16.0) | − 28.6(− 108.8, − 0.7) | 0.376 | 0.828 | 39.4(5.0, 82.6) | 42.5(12.1, 131.4) | −0.786 | 0.432 | 50.3(5.9, 128.3) | 39.5(12.3, 100.4) | 4.276 | 0.584 |
| PRL change from week 0 to 8 | 57.4(0.0, 131.5) | 46.4(25.3, 78.1) | 33.4(1.8, 66.2) | 0.71 | 0.492 | 33.4(1.8, 64.3) | 81.7(30.7, 133.7) | −2.179 | 0.029 | 37.2(18.0, 79.0) | 40.8(7.1, 82.9) | −0.399 | 0.690 |
| ESRS week 4 | 3 | 6 | 7 | 0.144 | 0.570 | 15 | 5 | −0.094 | 0.578 | 12 | 3 | −1.771 | 0.085 |
| ESRS week 8 | 3 | 7 | 10 | 0.525 | 0.828 | 15 | 5 | −0.094 | 0.578 | 13 | 4 | −1.740 | 0.094 |
| BAS week 4 | 1 | 4 | 3 | 0.741 | 0.693 | 4 | 3 | −1.167 | 0.353 | 5 | 3 | −0.152 | 0.598 |
| BAS week 8 | 1 | 5 | 3 | 0.596 | 0.653 | 7 | 2 | −0.124 | 0.634 | 4 | 5 | −0.912 | 0.472 |
Data are presented as median (interquartile range). Abbreviations: BAS Barnes Akathisia Scale, BMI Body mass index, CHO Cholesterol, ESRS Extrapyramidal Symptom Rating Scale, GLU Glucose, HDL High-density lipoprotein, LDL Low-density lipoprotein, PRL Prolactin, TG Triglyceride