Table 3.
Inflammation markers and infarct size in Obstructive-AMI and MINOCA patients, according to admission hyperglycemia
| Obstructive-AMI N = 2450 |
MINOCA N = 239 |
aHGL Obs-AMI vs MINOCA | |||||
|---|---|---|---|---|---|---|---|
| aHGL N = 977 |
aNGL N = 1473 |
p-value | aHGL N = 40 |
aNGL N = 199 |
p-value | p-value | |
| Inflammation markers (admission—T0) | |||||||
| WBC N/µl, median (IQR) | 10.5 (8.1–13.3) | 9.2 (7.4–11.6) | < 0.001 | 10.4 (8.1–14.9) | 8.1 (6.6–10.1) | < 0.001 | ns |
| Neutrophil N/µl, median (IQR) | 7197 (5385–10,249) | 6228 (4678–8623) | < 0.001 | 7933 (5637–11,443) | 5305 (4053–7361) | < 0.001 | ns |
| Lymphocyte N/µl, median (IQR) | 1710 (1187–2530) | 1787 (1312–2496) | 0.2 | 1736 (1165–2164) | 1840 (1385–2310) | 0.3 | ns |
| PLTs count × 109 per L, median (IQR) | 233 (193–282) | 228 (189–275) | 0.1 | 234 (195–287) | 239 (200–289) | 0.8 | ns |
| CRP mg/dL, median (IQR) | 0.5 (0.2–1.4) | 0.4 (0.2–0.8) | < 0.001 | 0.5 (0.2–1.6) | 0.3 (0.1–0.7) | 0.04 | ns |
| Inflammation markers (24 h—T1) | |||||||
| WBC N/µl, median (IQR) | 9.7 (7.9–12.3) | 8.7 (7.0–10.9) | < 0.001 | 7.9 (7.0–10.9) | 7.4 (6.2–8.8) | 0.04 | 0.008 |
| Neutrophil N/µl, median (IQR) | 6935 (5344–9392) | 5881 (4425–7730) | < 0.001 | 5505 (3851–9122) | 4590 (3519–6527) | 0.08 | 0.026 |
| Lymphocyte N/µl, median (IQR) | 1688 (1187 – 2219) | 1839 (1376 –2407) | < 0.001 | 2012 (1042 – 2419) | 1817 (1367 – 2304) | 0.9 | ns |
| CRP mg/dL, median (IQR) | 1.1 (0.4 – 4.3) | 0.7 (0.3 – 1.8) | < 0.001 | 1.0 (0.4 – 2.3) | 0.5 (0.2 – 1.0) | 0.06 | ns |
| Infarct size | |||||||
| LVEDV ml, median (IQR) | 108 (84 – 135) | 100 (83 – 121) | 0.003 | 80 (70 – 121) | 89 (74 – 107) | 0.7 | 0.016 |
| LV EF %, median (IQR) | 47 (40 – 56) | 55 (45 – 60) | < 0.001 | 59 (50 – 61) | 60 (53 – 62) | 0.8 | < 0.001 |
| Peak hs Troponin ng/L, median (IQR) | 6556 (959 – 35,531) | 2936 (576 – 18,164) | < 0.001 | 369 (133 – 901) | 461 (113 – 1661) | 0.5 | < 0.001 |
Continuous variables are presented as median (IQR) while categorical ones as n (%).AMI Acute myocardial infarction, MINOCA Myocardial infarction with non-obstructive coronary arteries, Obs-AMI Obstructive acute myocardial infarction, aHGL Admission high glucose level, aNGL Admission normal glucose level, WBC White blood cell, PLTs Platelets, NLR Neutrophil-to-lymphocyte ratio, PLR Platelet-to-lymphocyte ratio, NPR Neutrophil-to-platelet ratio, CRP C-reactive protein, LVEDV Left ventricular end diastolic diameter; LVEDV Left ventricular end diastolic volume, LVEF Left ventricular ejection fraction, Hs High sensitivity