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. 2021 Feb 7;27(5):404–415. doi: 10.3748/wjg.v27.i5.404

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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Histology of two “probably reversing” cases before and after sustained virologic response with direct-acting antivirals. Patient 1 is a 55-year-old male with genotype 1b treated with daclatasvir + asunaprevir for 24 wk: Pre-histology activity index (HAI) 14, pre-Ishak 6, pre-predominantly progressive, indeterminate and predominately regressive (P-I-R) predominantly progressive, post-HAI 4, post-Ishak 6, post-P-I-R predominantly progressive. Patient 2 is a 39-year-old female with genotype 3 treated with sofosbuvir + ribavirin for 24 wk: Pre-HAI 6, pre-Ishak 3, pre-P-I-R indeterminate, post-HAI 3, post-Ishak 3, post-P-I-R predominately regressive. Hematoxylin and eosin (10 ×); Masson’s trichrome (4 ×); reticulin (4 ×). H/E: hematoxylin and eosin.