Table 3.
IC50 values of TMZ, PTX, and SynB3‐PVGLIG‐PTX toward U87MG, U251, and their MMP‐2 siRNA‐transfected cell lines
| Group | IC50 [× 10−6 м] a) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| U87MG | U87MG+MMP‐2 siRNA | U251 | U251+MMP‐2 siRNA | |||||||||
| 4 h | 24 h | 48 h | 4 h | 24 h | 48 h | 4 h | 24 h | 48 h | 4 h | 24 h | 48 h | |
| TMZ | 392.123 | 382.285 | 514.467 | 470.585 | 413.904 | 280.138 | 3072.756 | 660.490 | 212.816 | 3298.487 | 869.053 | 130.888 |
| PTX | 148.470 | 46.321 | 31.285 | 208.942 | 37.258 | 28.519 | 180.545 | 47.130 | 27.350 | 135.507 | 31.542 | 23.624 |
| SynB3‐PVGLIG‐PTX | 139.541 | 45.787 | 31.981 | 311.219 | 219.364 | 172.180 | 115.846 | 41.413 | 27.366 | 165.602 | 207.674 | 176.806 |
a)
IC50 values denote the concentrations of different drugs necessary for 50% inhibition of cell proliferation activity. The periods of drug treatment were 4, 24, and 48 h.