Figure 6.

BCL‐XL and WEE1 targeting leads to perturbation of several signals, including epigenetic, DNA damage/repair, apoptosis, and cell cycle regulators. a) Graph showing the fold change (Log₂) of protein phosphorylation or expression in MGT4 cells between: A1155463 (A11) versus untreated (on the x‐axis), Adavosertib (Adav) versus untreated (on the y‐axis), and the combination versus untreated (colors of the dots). Changes related to epigenetics (HistoneH3, H3K9me2, phosphoS₁₀HistoneH3, U‐HistoneH2B, RRM2) DNA damage and repair (γH2AX, Rad51, PAR), apoptosis (cleaved Caspase7, cleaved Caspase3), and cell cycle (CHK1, CDK1, cyclins) are indicated. b) Changes in the expression/phosphorylation levels of the reported proteins in MGT4 cells untreated and treated with the indicated drugs, based on RPPA analysis (Table S7, Supporting Information). P‐values were determined by the Limma package in R.