Table 1.
FGE.13Rev3 – candidate and supporting substances divided into subgroups of related chemical structures. Substances listed in bold are the candidate substances in this FGE. The supporting substances from the 55th, 59th, 65th, 69th, 76th and 86th JECFA meetings and EFSA (EFSA, 2004b) are in normal type face
| FL‐no JECFA‐no | EU Register name | Structural formula | EFSA status according to FGE.13Rev2 |
|---|---|---|---|
| Main Group I: non‐sulfur‐containing furan derivatives | |||
| Subgroup Ia Structurally Related to Furfuryl alcohol | |||
| 13.011 | Ethyl furfuracrylate |
|
FGE.13 Rev1 – no safety concern |
| 13.102 | Butyl 2‐furoate |
|
FGE.13 – no safety concern |
| 13.122 | Ethyl 2‐furoate |
|
FGE.13 – no safety concern |
| 13.127 | Furfuryl 2‐methylbutyrate |
|
FGE.13 Rev1 – no safety concern |
| 13.129 | Furfuryl but‐2-enoate |
|
FGE.13 Rev1 – no safety concern |
| 13.130 | Furfuryl butyrate |
|
FGE.13 Rev2 – no safety concern |
| 13.132 | Furfuryl hexanoate |
|
FGE.13 – no safety concern |
| 13.133 | Furfuryl isobutyrate |
|
FGE.13 – no safety concern |
| 13.136 | 2‐Furoic acid |
|
FGE.13 – no safety concern |
| 13.139 | 5‐Hydroxymethylfurfuraldehyde |
|
FGE.13 Rev2 – no safety concern |
|
13.001 745 |
5‐Methylfurfuralb |
|
FGE.66 Rev1 – no safety concern |
|
13.002 746 |
Methyl 2‐furoateb |
|
FGE.66 Rev1 – no safety concern |
|
13.003 747 |
Propyl 2‐furoateb |
|
FGE.66 Rev1 – no safety concern |
|
13.018 450 |
Furfuralb |
|
FGE.66 Rev1 – no safety concern |
|
13.019 451 |
Furfuryl alcoholb |
|
FGE.66 Rev1 – no safety concern |
|
13.057 743 |
Furfuryl isovalerateb |
|
FGE.66 Rev1 – no safety concern |
|
13.062 740 |
Furfuryl propionateb |
|
FGE.66 Rev1 – no safety concern |
|
13.068 741 |
Furfuryl valerateb |
|
FGE.66 Rev1 – no safety concern |
| 13.126 | Furfuryl diethyl acetalb |
|
Supporting substance from the Register and evaluated by the AFC Panel (EFSA, 2004b). Substance not in the Union List |
|
13.128 739 |
Furfuryl acetateb |
|
FGE.66 Rev1 – no safety concern |
|
13.005 749 |
Hexyl 2‐furoateb |
|
FGE.66 Rev1 – no safety concern |
|
13.025 748 |
Pentyl 2‐furoateb |
|
FGE.66 Rev1 – no safety concern |
|
13.038 752 |
2‐Phenyl‐3‐carbethoxyfuranb |
|
FGE.66 Rev1 – no safety concern |
|
13.067 742 |
Furfuryl octanoateb |
|
FGE.66 Rev1 – no safety concern |
|
13.073 750 |
Octyl 2‐furoateb |
|
FGE.66 Rev1 – no safety concern |
| Subgroup Ib Alkoyl‐substituted furans | |||
| 13.155 | 2‐Methyl‐5-propionylfuran |
|
Not supported as candidate substance in this FGE (DG SANCO, 2012) and not included in the Union List |
|
13.054 1503 |
2‐Acetylfuranb |
|
To be evaluated in FGE.67Rev3 |
|
13.066 1506 |
3‐Acetyl‐2,5‐dimethylfuranb |
|
No longer supportedd |
|
13.070 1512 |
2‐Hexanoylfuranb |
|
To be evaluated in FGE.67Rev3 |
|
13.083 1504 |
2‐Acetyl‐5‐methylfuranb |
|
To be evaluated in FGE.67Rev3 |
|
13.101 1505 |
2‐Acetyl‐3,5‐dimethylfuranb |
|
To be evaluated in FGE.67Rev3 |
|
13.105 1507 |
2‐Butyrylfuranb |
|
To be evaluated in FGE.67Rev3 |
|
13.163 1509 |
2‐Pentanoylfuranb |
|
To be evaluated in FGE.67Rev3 |
| Subgroup Ic Alkyl‐substituted furans | |||
| 13.125 | 2‐Ethyl‐5-methylfuran |
|
To be evaluated in FGE.13 Rev3 |
| 13.162 | 2‐Octylfuran |
|
To be evaluated in FGE.13 Rev3 |
|
13.029 1488 |
2,5‐Dimethylfuranb |
|
Deleted from ULa |
|
13.030 1487 |
2‐Methylfuranb |
|
Deleted from ULa |
|
13.092 1489 |
2‐Ethylfuranb |
|
Deleted from ULa |
|
13.059 1491 |
2‐Pentylfuranb |
|
To be evaluated in FGE.67Rev3 |
|
13.069 1492 |
2‐Heptylfuranb |
|
To be evaluated in FGE.67Rev3 |
|
13.103 1490 |
2‐Butylfuranb |
|
No longer supportedc |
|
13.106 1493 |
2‐Decylfuranb |
|
To be evaluated in FGE.67Rev3 |
|
13.148 1494 |
3‐Methyl‐2(3‐methylbut‐2‐enyl)furanb |
|
To be evaluated in FGE.67Rev3 |
| Main Group II: Sulfur‐substituted Furan Derivatives | |||
| Subgroup IIa Sulfides | |||
| 13.114 | 2,5‐Dimethyl‐3-(methylthio)furan |
|
FGE.13 – no safety concern |
| 13.124 | Ethyl furfuryl sulfide |
|
FGE.13 – no safety concern |
| 13.135 | 1‐(2-furfurylthio)‐propanone |
|
FGE.13 Rev1 – no safety concern |
| 13.141 | Methyl (2‐furfurylthio)acetate |
|
FGE.13 Rev1 – no safety concern |
| 13.143 | Methyl 3‐(furfurylthio)propionate |
|
FGE.13 Rev1 – no safety concern |
| 13.145 | Methyl 5‐methylfurfuryl sulfide |
|
FGE.13 – no safety concern |
| 13.199 | 3‐[(2-methyl‐3-furyl)thio]‐butanal |
|
FGE.13 Rev2 – no safety concern |
|
13.053 1076 |
Methyl furfuryl sulfideb |
|
FGE.65 Rev1 – no safety concern |
|
13.056 1080 |
Difurfuryl sulfideb |
|
FGE.65 Rev1 – no safety concern |
|
13.065 1062 |
2‐Methyl‐5‐(methylthio)furanb |
|
FGE.65 Rev1 – no safety concern |
|
13.152 1061 |
2‐Methyl‐3‐(methylthio)furanb |
|
FGE.65 Rev1 – no safety concern |
|
13.196 1084 |
4‐(Furfurylthio) pentan‐2‐oneb |
|
FGE.65 Rev1 – no safety concern |
|
13.032 1077 |
Furfuryl isopropyl sulfideb |
|
FGE.65 Rev1 – no safety concern |
|
13.075 1086 |
2,6‐Dimethyl‐3‐((2‐methyl‐3‐furyl)thio)heptan‐4‐oneb |
|
FGE.65 Rev1 – no safety concern |
|
13.077 1085 |
3‐((2‐Methyl‐3‐furyl)thio)heptan‐4‐oneb |
|
FGE.65 Rev1 – no safety concern |
|
13.078 1087 |
4‐((2‐Methyl‐3‐furyl)thio)nonan‐5‐oneb |
|
FGE.65 Rev1 – no safety concern |
|
13.093 1088 |
Ethyl 3‐(2‐furfurylthio)propionateb |
|
FGE.65 Rev1 – no safety concern |
|
13.151 1082 |
2‐Methyl‐3,5 and 6‐(furfurylthio)pyrazineb |
|
FGE.65 Rev1 – no safety concern |
| Subgroup IIb Thiols | |||
| 13.149 | 5‐Methyl‐2-furanmethanethiol |
|
FGE.13 – no safety concern |
| 13.108 | 4,5‐Dihydro‐3-mercapto‐2-methylfuran |
|
FGE.13 – no safety concern |
|
13.026 1072 |
2‐Furanmethanethiolb |
|
FGE.65 Rev1 – no safety concern |
|
13.055 1060 |
2‐Methylfuran‐3‐thiolb |
|
FGE.65 Rev1 – no safety concern |
|
13.071 1063 |
2,5‐Dimethylfuran‐3‐thiolb |
|
FGE.65 Rev1 – no safety concern |
|
13.160 1090 |
2‐Methyltetrahydrofuran‐3‐thiolb |
|
FGE.65 Rev1 – no safety concern |
|
13.193 1091 |
2,5‐Dimethyltetrahydro‐3‐furanthiolb |
|
FGE.65 Rev1 – no safety concern |
| Subgroup IIc Disulfides | |||
| 13.113 | 2,5‐Dimethyl‐3-(methyldithio)furan |
|
FGE.13Rev1 – no safety concern |
| 13.144 | Methyl 5‐methylfurfuryl disulfide |
|
FGE.13 – no safety concern |
| 13.178 | 3‐(Furfuryldithio)‐2-methylfuran |
|
FGE.13 – no safety concern |
| 13.185 | 2‐Furfuryl 3‐oxo-2‐butyl disulfide |
|
FGE.13 Rev2 – no safety concern |
|
13.016 1066 |
bis‐(2‐Methyl‐3‐furyl) disulfideb |
|
FGE.65 Rev1 – no safety concern |
|
13.050 1081 |
Difurfuryl disulfideb |
|
FGE.65 Rev1 – no safety concern |
|
13.064 1078 |
Methyl furfuryl disulfideb |
|
FGE.65 Rev1 – no safety concern |
|
13.082 1065 |
Propyl 2‐methyl‐3‐furyl disulfideb |
|
FGE.65 Rev1 – no safety concern |
|
13.079 1064 |
Methyl 2‐methyl‐3‐furyl disulfideb |
|
FGE.65 Rev1 – no safety concern |
|
13.197 1079 |
Furfuryl propyldisulfideb |
|
FGE.65 Rev1 – no safety concern |
|
13.015 1067 |
bis‐(2,5‐Dimethyl‐3‐furyl) disulfideb |
|
FGE.65 Rev1 – no safety concern |
| Subgroup IId Polysulfides | |||
| 13.146 | Methyl furfuryl trisulfide |
|
FGE.13 – no safety concern |
|
13.017 1068 |
bis‐(2‐Methyl‐3‐furyl) tetrasulfideb |
|
FGE.65 Rev1 – no safety concern |
a
Commission Regulation (EU) No 246/2014 of 13 March 2014 amending Annex I to Regulation (EC) No 1334/2008 of the European Parliament and of the Council as regards removal from the Union list of certain flavouring substances. OJ L74, 14.3.2014, p. 58–60.
b
Supporting substances for each subgroup.
c
Letter from DG‐SANTE to EFSA (DG SANTE, 2020a).
d
Letter from DG‐SANTE to EFSA (DG SANTE, 2020b).