. 2021 Feb 3;19(2):e06386. doi: 10.2903/j.efsa.2021.6386

Table H.1.

Summary of in vitro genotoxicity data evaluated in FGE.67Rev3

Chemical name [FL‐no]	Test system	Test object	Concentrations of substance and test conditions (μg/mL)	Result	Reference	Comments
2‐acetylfuran [13.054]	Micronucleus assay	Human peripheral blood lymphocytes	From 34.7 to 1,111^(a),(b),(c)	Negative	Charles River (2020a)	Reliable without restrictions. Study performed in compliance with OECD TG 487 and GLP
2‐pentylfuran [13.059]	Micronucleus assay	Human peripheral blood lymphocytes	From 54.5 to 100.8^(a),(b) From 51.4 to 91.1c	Negative	Charles River (2020b)	Reliable without restrictions. Study performed in compliance with OECD TG 487 and GLP

Chemical name [FL‐no]

Test system

Test object

Concentrations of substance and test conditions (μg/mL)

Result

Reference

Comments

2‐acetylfuran

[13.054]

Micronucleus assay

Human peripheral blood lymphocytes

From 34.7 to 1,111^(a),(b),(c)

Negative

Charles River (2020a)

Reliable without restrictions. Study performed in compliance with OECD TG 487 and GLP

2‐pentylfuran

[13.059]

Micronucleus assay

Human peripheral blood lymphocytes

From 54.5 to 100.8^(a),(b)

From 51.4 to 91.1c

Negative

Charles River (2020b)

Reliable without restrictions. Study performed in compliance with OECD TG 487 and GLP

Without S9 metabolic activation, 4 + 20 h treatment.

With S9 metabolic activation, 4 + 20 h treatment.

Without S9 metabolic activation, 24 h treatment.