. 2021 Feb 3;19(2):e06386. doi: 10.2903/j.efsa.2021.6386

Table I.1.

Summary of toxicity data evaluated in FGE.67Rev3

Chemical name [FL‐no]	Species; Sex No/group	Route	Doses (mg/kg bw per day)	Duration (days)	NOAEL or BMDL (mg/kg bw per day)	Reference	Comments
2‐acetylfuran [13.054]	Rat; M & F; 32 rats for control and lowest dose; 12 rats for the mid dose; 10 rats for the highest dose	Diet	0, 5, 25, 100 (nominal)	28		Bio‐Research Laboratories (1985)
2‐acetylfuran [13.054]		Diet	0, 5, 25 (nominal, equal to 22.6 in males and 27 in females)	90	22.6		Study conducted according to OECD TG 408 and GLP
2‐pentylfuran [13.059]	Mice; M & F; 5 animals/group	Gavage	0, 800, 1,000, 1,260, 1,600, 2,000	Single dose acute toxicity study	LD50 about 1,200 mg/kg	Gulf South Research Institute (1971a)	Only summary available
	Rats; M & F; 23 animals/group	Diet	0, 25.6	90	–	Gulf South Research Institute (1971b)
	Rat; M & F 5/sex/dose level	Diet	0, 100, 250 and 500	14	–	Product Safety Labs (2016)
	Rat; M & F 10/sex/dose level	Oral gavage	0, 30, 100 and 150	90	8.51	Product Safety Labs (2017)	Study conducted according to OECD TG 408 and GLP. Value 8.51 is BMDL₂₂. The study authors proposed a NOAEL of 30 mg/kg bw per day