Table 1.
ORs (95% CI) for the association between recency, dose and duration of low-dose aspirin and risk of UGIB.
| Low-dose aspirin | UGIB cases N = 1843 n (%) |
Controls N = 5000 n (%) |
OR (95% CI)a | OR (95% CI)b |
|---|---|---|---|---|
| Recency | ||||
| Non-usec | 672 (36.5) | 2412 (48.2) | 1 (–) | 1 (–) |
| Current use (0–30 days) | 987 (53.6) | 2160 (43.2) | 1.41 (1.25–1.59) | 1.53 (1.34–1.75) |
| Recent use (31–90 days) | 83 (4.5) | 181 (3.6) | 1.36 (1.02–1.80) | 1.49 (1.11–2.00) |
| Past use (91–365 days) | 101 (5.5) | 247 (4.9) | 1.18 (0.91–1.52) | 1.13 (0.87–1.48) |
| Dosed | ||||
| 75 mg | 912 (49.5) | 2028 (40.6) | 1.39 (1.23–1.57) | 1.50 (1.31–1.71) |
| 150 mg | 63 (3.4) | 111 (2.2) | 1.80 (1.29–2.50) | 1.96 (1.39–2.76) |
| 300 mg | 12 (0.7) | 21 (2.2) | 1.97 (0.94–4.13) | 2.39 (1.12–5.12) |
| Duration of used | ||||
| <3 months | 172 (9.3) | 286 (5.7) | 1.86 (1.50–2.31) | 1.89 (1.51–2.37) |
| 3–<6 months | 110 (6.0) | 203 (4.1) | 1.58 (1.22–2.05) | 1.75 (1.34–2.29) |
| 6 months–<1 year | 150 (8.1) | 320 (6.4) | 1.35 (1.08–1.68) | 1.39 (1.10–1.75) |
| 1–<5 years | 442 (24.0) | 1043 (20.9) | 1.35 (1.16–1.56) | 1.48 (1.26–1.73) |
| ≥5 years | 113 (6.1) | 308 (6.2) | 1.19 (0.94–1.52) | 1.34 (1.04–1.73) |
Adjusted by age, sex, calendar year and number of PCP visits in the year prior to the index date.
Adjusted by age, sex, calendar year, number of PCP visits in the year prior to the index date, smoking, alcohol consumption, history of UGIB, history of LGIB, history of unspecified GIB, pancreatic disease, uncomplicated PU problems, polypharmacy, use of NSAIDs, PPIs, clopidogrel and warfarin.
Non-use was defined as either never use (no recorded use before the index date) or distant use (use more ≥365 days before the index date).
Among current users of low-dose aspirin.
CI: confidence interval; GIB: gastrointestinal bleed; LGIB: lower gastrointestinal bleed; NSAIDs: non-steroidal-inflammatory drugs; PCP: primary care practitioner; PPIs: proton pump inhibitors; PU: peptic ulcer; OR: odds ratio; UGIB: upper gastrointestinal bleed.