Table 1.

Data summary

Study ID	NCT	Study Design	Population	Duration of treatment	Intervention	Comparison
Toy et al. 2016	-	Prospective, Randomize, Fellow eye-controlled clinical trial	71 patients	12 months follow up	WFO-PRK using the WaveLight Allegretto Eye-Q 400-Hz (Alcon)	WFG-PRK using the VISX CustomVue Star S4 IR
Sia et al. 2015	-	Prospective randomized open-label study	108 patients	(1,3,6,12) months follow up	Wavefront-guided	Wavefront-optimized treatment
Ryan et al. 2017	1097525	prospective, randomized clinical trial	56 patients	(6,12) months follow up	Wavefront-guided (WFG)	Wavefront-optimized (WFO) photorefractive keratectomy (PRK)
Moshirfar et al. 2011	-	Prospective, single-masked, randomized, fellow-eye study	23 patients	Three months follow up	WaveLight Allegretto system (Wavefront-optimized group), which utilizes the WaveLight® Allegretto 400 Hz Wave® Eye-Q Laser	VISX CustomVueTM STAR S4 IRTM Excimer Laser with Active Track
Maurer et al. 2014	-	prospective randomized study	27 patients	(1,3,6) months follow up	WFG PRK, WFG LASIK	WFO PRK and WFG LASIK
Lee et al. 2016	1135719	prospective randomized study	68 patients	12 months follow up	Wavefront-guided PRK (VISX CustomVue Star S4 IR excimer laser system	Wavefront-optimized PRK (WaveLight Allegretto Wave EyeQ 400 Hz excimer laser system; Alcon Laboratories, Inc., Fort Worth, TX)
He et al. 2015	1135719	Prospective, randomized, fellow-eye controlled clinical trial	71 patients	(1,3,6,12) months follow up	WFG PRK (Visx CustomVue Star S4IR excimer laser system; Abbott Medical Optics)	WFO PRK (WaveLight Allegretto Wave Eye-Q 400 Hz excimer laser system; Alcon Surgical)
He et al. 2014	1135719	Prospective, randomized, fellow eye controlled study	71 patients	(1,3,6,12) months follow up	WFG PRK treatment by the VISX CustomVue Star S4 IR excimer laser system	WFO PRK treatment by the WaveLight Allegretto Wave Eye-Q 400 Hz excimer laser system