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. 2021 Jan 20;10:602694. doi: 10.3389/fonc.2020.602694

Figure 6.

Figure 6

circ_NOTCH3 promotes the progression of BLBC by regulating KLF12 expression through sponges miR-205-5p. (A) RT-qPCR showed that the relative expression of KLF12 was knocked down by siRNA transfection and upregulated by pCD-RNA transfection. (B) The relative expression of KLF12 was markedly increased by the overexpression of circ_NOTCH3. The relative expression of KLF12 was decreased by the overexpression of miR-205-5p and restored by the simultaneous co-expression of circ_NOTCH3 and miR-205-5p. (C) Western blotting showed that the relative protein expression of KLF12 was knocked down by siRNA transfection and upregulated by pCD-RNA transfection. (D) The relative protein expression of KLF12 was significantly increased by the overexpression of circ_NOTCH3, markedly decreased by the overexpression of miR-205-5p, and restored by the simultaneous co-expression of circ_NOTCH3 and miR-205-5p. *P < 0.05 and **P < 0.01. circ, circulating; mi, micro; si, small interfering; BLBC, basal-like breast carcinoma.