Table 3.

Sixteen FDA-approved drugs showing the highest affinity for SARS-CoV-2 PL^pro.

Drug	Binding affinity	Current application
Biltricide	8 nM-8 μM	Anthelmintic
Cinacalcet	26 nM-3 μM	Calcimimetic, treatment of hyperparathyroidism
Procainamide	30 nM-3 μM	Antiarrhythmic
Terbinafine	33 nM-3 μM	Antifungal
Pethidine	53 nM-5 μM	Narcotic analgesic
Labetalol	113 nM-11 μM	Treatment of hypertension
Tetrahydrozoline	137 nM-14 μM	Over-the-counter eye drops and nasal spray
Ticlopidine	160 nM-16 μM	Inhibitor of platelet aggregation
Ethoheptazine	163 nM-16 μM	Opioid analgesic
Formoterol	716 nM-71 μM	Management of COPD and asthma
Amitriptyline	466 nM-46 μM	Antidepressant with analgesic properties
Naphazoline	697 nM-69 μM	Decongestant in over-the-counter eye drops and nasal preparations
Levamisole	259 nM-26 μM	Antihelminthic used for parasitic, viral, and bacterial infections
Benzylpenicillin	718 nM-71 μM	Narrow-spectrum antibiotic
CQ	858 nM-85 μM	Antimalarial agent
Chlorothiazide	939 nM-93 μM	Diuretic