Table 2.
Intradialytic clinical monitoring and intradialytic variables related to Regional Citrate Anticoagulation.
| Variable | SLED Start | SLED 2 h | SLED 6 h | SLED 10 h | SLED 12 h | P | |
|---|---|---|---|---|---|---|---|
| SBP, mmHg | 130.1 (20.4) | 129.0 (24.0) | 119.9 (23.2) | 117.2 (24.4) | 118.4 (15.0) | 0.0046 | |
| DBP, mmHg | 62.2 (10.55) | 62.2 (13.98) | 61.6 (9.48) | 60.7 (11.53) | 61.1 (11.42) | NS | |
| Heart rate, bpm | 94.9 (12.4) | 96.8 (13.5) | 96.9 (14.8) | 100.2 (13.5) | 94.5 (15.2) | NS | |
| Dopamine, mcg/Kg/min | 0.73 (2.08) | 0.67 (1.98) | 0.89 (2.47) | 0.78 (2.27) | 0.71 (2.28) | NS | |
| Norepinephrine, mcg/Kg/min | 0.06 (0.11) | 0.06 (0.11) | 0.06 (0.14) | 0.05 (0.15) | 0.05 (0.15) | NS | |
| Dobutamine, mcg/Kg/min | 0.14 (0.37) | 0.14 (0.37) | 0.14 (0.37) | 0.09 (0.31) | 0.09 (0.31) | NS | |
| SpO2, % | 97.5 (2.9) | 98.0 (2.1) | 97.2 (6.6) | 98.6 (1.7) | 99.3 (0.8) | NS | |
| FiO2, % | 50.9 (20.0) | 50.3 (18.1) | 51.4 (18.6) | 50.6 (17.5) | 51.1 (15.0) | NS | |
| ACT, sec | 110.6 (10.53) | 111.8 (10.54) | 116.8 (10.87) | 110.9 (6.33) | 109.1 (14.25) | NS | |
| Ionized calcium (s-Ca2+), mmol/L | 1.16 (0.08) | 1.12 (0.07) | 1.16 (0.07) | 1.15 (0.08) | 1.16 (0.08) | NS | |
| Bicarbonate (HCO3−), mmol/L | 24.4 (2.6) | 24.7 (2.7) | 24.6 (1.8) | 25.9 (3.2) | 26.5 (1.1) | ||
Data are presented as mean (SD). Values were measured on patients' arterial line if not otherwise indicated.
Abbreviations: SLED, Sustained Low Efficiency Dialysis; SBP, Systolic Blood Pressure; DBP, Diastolic Blood Pressure; SpO2, Peripheral Oxygen Saturation, FiO2, Fraction of Inspired Oxygen; ACT, Activated coagulation time; NS, not statistically significant.