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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Int J Radiat Oncol Biol Phys. 2020 Jul 3;108(1):46–55. doi: 10.1016/j.ijrobp.2020.06.067

Table 2.

The effect of differing RT schemes on immune cell populations. DC = Dendritic cells, Treg = Regulatory T cell, Ag = Antigen, MDSC = Myeloid Derived Suppressor Cell

Classical Fractionated Hypofractionated Low Dose High Dose
Macrophage and DC Infiltration (54)
Maturation of DC’s (58)
Increased Ag Presentation (54)		 Suppresses MDSC’s (59, 62)
Maturation of DC’s (58, 59)
CD8+ T Cell Activation (59)		 M1 Macrophage Phenotype (52) CD8+T Cell Activation (52)
Maturation of DC’s (53)
Macrophage and DC Infiltration (54)
Increased Ag Presentation (54)
CD8+ T Cell Inhibition (52)
Infiltration of Tregs (52, 57)		 Late Infiltration of Tregs (59)
Infiltration of Tregs (52, 56, 57)
M2 Macrophage Phenotype (52)