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. Author manuscript; available in PMC: 2021 Jun 1.
Published in final edited form as: Psychopharmacology (Berl). 2020 Mar 3;237(6):1709–1721. doi: 10.1007/s00213-020-05486-z

Figure 2. Acute stress reduced days to acquire heroin self-administration and increased stress reactivity following extinction.

Figure 2.

A) Stress rats acquired the lever press response for heroin in fewer days than sham rats. B) Active lever presses in stress and sham rats self-administering heroin did not differ between stress groups. C) There were no differences between sham and stress rats on the first day of extinction with the stress/sham CS. Sham and stress rats all extinguished lever press responding over the 8 days of extinction. Sham rats had increased responding on extinction day 1 relative to stress rats in response to the sham CS. E) Stress rats lever pressed more in response to the stress CS relative to sham rats. Both groups reinstated to heroin conditioned cues. F) Stress rats responded more than sham rats in response to daily extinction with the heroin conditioned cue combined with the stress/sham CS

* Indicates significant difference between stress and sham groups, p<0.05.