Table 3.

Pooled Estimates of the Associations Between Higher CMV IgG Antibody Quartiles With All-Cause and Cardiovascular Mortality, Compared to the Lowest CMV IgG Quartile

Cytomegalovirus	All-Cause Mortality, HR (95% CI)			Cardiovascular Mortality, HR (95% CI)
	Model 1b	Model 2c	Model 3c	Model 1b	Model 2c	Model 3c
IgG antibody quartile 1a	1	1	1	1	1	1
IgG antibody quartile 2	1.01 (.78–1.30)	0.99 (.87–1.14)	0.98 (.85–1.21)	0.99 (.68–1.44)	0.88 (.60–1.29)	0.87 (.60–1.26)
IgG antibody quartile 3	1.06 (.95–1.20)	1.08 (.95–1.23)	1.09 (.90–1.31)	1.09 (.70–1.68)	1.24 (.70–2.20)	1.24 (.69–2.21)
IgG antibody quartile 4	1.18 (.98–1.42)	1.18 (.91–1.54)	1.15 (.89–1.49)	1.05 (.62–1.79)	1.01 (.48–2.09)	0.99 (.48–2.06)

Cox regression analyses within individual cohorts (Supplementary Table 1) were performed in 3 models:

Model 1: adjustment for age and sex (for PROSPER, also country and statin use);

Model 2: adjustment for model 1 plus body mass index, education, smoking status, number of comorbidities, and medications;

Model 3: adjustment for model 2 plus log transformed C-reactive protein.

Abbreviations: CMV, cytomegalovirus; CI, confidence interval; HR, hazard ratio; IgG, immunoglobulin G.

^aCMV IgG antibody quartile 1 was the reference group.

^bAll cohorts included.

^cAll cohorts except for Leiden Longevity Study (LLS) F1 and F2.