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The mean middle ear (ME) areas covered by inflammatory cells. Leukocyte infiltration peaked at days 3 after NTHi inoculation and then decreased. Although CCR2−/−/PBS MEs, and especially CCR2−/−/CL MEs, exhibited higher levels of inflammatory cell infiltration than wild-type (WT) MEs that was sustained through day 7 after bacterial inoculation, the differences were not statistically significant.
