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. 2020 Jun 23;223(2):333–341. doi: 10.1093/infdis/jiaa353

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Published by Oxford University Press for the Infectious Diseases Society of America 2020.

This work is written by (a) US Government employee(s) and is in the public domain in the US.

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Figure 6. — The numbers of macrophages in a 400× field of middle ear (ME) infiltrate. In wild-type (WT) MEs, the number of macrophages peaked at 2–3 days, and very few were observed at 7 days. Substantially fewer macrophages were observed in CCR2^−/−/CL MEs than WT MEs on days 2 (P < .05, 2-way analysis of variance) and 3 after infection. On day 7, few macrophages were observed in WT MEs, consistent with the resolution of otitis media, but macrophages remained in the MEs of CCR2^−/−/PBS and CCR2^−/−/CL mice. HPF, high-power field.