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. 2020 Nov 26;15(30):2933–2953. doi: 10.2217/nnm-2020-0344

Figure 5. . Effects of SCD-19 and poly lactic-co-glycolic acid SCD-19 nanoparticles on heat killed Pseudomonas aeruginosa and P. aeruginosa filtrate induced TNF-α and RANTES protein production.

Figure 5. 

SCD-19 (100 μM) inhibits Heat Killed Pseudomonas aeruginosa (HKPA) mediated (A) TNF-α and (B) RANTES protein production. Nanopackaged SCD-19 inhibits HKPA mediated (C) TNF-α and (D) RANTES protein production. SCD-19 inhibits P. aeruginosa filtrate (PPF) mediated (E) TNF-α but not (F) RANTES protein production. poly lactic-co-glycolic acid-SCD-19 (PLGA-SCD-19) nanoparticles (100 μM) inhibits PPF mediated (G) TNF-α and (H) RANTES protein production. Protein expression was measured by ELISA. Data are presented as mean ± SEM of 3 independent experiments with 3 technical replicates. A One-way ANOVA with a Tukey's multiple comparison post-hoc test was used to test for statistical differences. (A & B) ***p < 0.001; DMSO compared with HKPA. ††† p < 0.001; HKPA compared with SCD-19 + HKPA. (C & D) ***p < 0.001; PLGA compared with PLGA + HKPA. †††p < 0.001; PLGA + HKPA compared with PLGA SCD-19 + HKPA. (E, F) ***p < 0.001; DMSO compared with PPF. †††p < 0.001; PPF compared with SCD-19 + PPF. (G & H) **p < 0.05; ***p < 0.001; PLGA compared with PLGA + PPF. †p < 0.01, †††p < 0.001; PLGA + PPF compared with PLGA-SCD-19 nanoparticles + PPF.