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. 2020 Sep 24;370(6519):950–957. doi: 10.1126/science.abe3354

Fig. 3. The S2M11 neutralizing mAb recognizes a quaternary epitope spanning two RBDs and stabilizes S in the closed state.

Fig. 3

(A and B) Cryo-EM structure of the prefusion SARS-CoV-2 S ectodomain trimer bound to three S2M11 Fab fragments viewed along two orthogonal orientations. (C and D) The S2M11 binding pose, which involves a quaternary epitope spanning two neighboring RBDs. (E and F) Close-up views showing selected interactions formed between S2M11 and the SARS-CoV-2 RBDs. In (A) to (F), each SARS-CoV-2 S protomer is colored distinctly (cyan, pink, and gold), whereas the S2M11 light- and heavy-chain variable domains are colored magenta and purple, respectively. N-linked glycans are rendered as blue spheres in (A) to (D) and as sticks in (E) and (F). FR, framework.