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. 2020 Oct 9;370(6520):1110–1115. doi: 10.1126/science.abe2402

Fig. 3. Efficacy of REGN-COV2 in treatment and prophylaxis in the golden Syrian hamster model of SARS-CoV-2 infection.

Fig. 3

(A) Overview of study design. (B) Impact of REGN-COV2 on weight loss in prophylaxis and treatment groups. Error bars represent mean with error. IgG1, immunoglobulin G1. (C) Impact of REGN-COV-2 prophylaxis on levels of gRNA and sgRNA in hamster lungs (7 days after infection). No statistical significance was observed between any treatment groups and placebo. The dotted lines indicate limit of detection (LOD = 200 GE/ml for gRNA and LOD = 200 SGE/ml for sgRNA), and error bars represent median with 95% confidence intervals. (D) Impact of REGN-COV2 prophylaxis on percent area of lung exhibiting pathology typical of pneumonia (****p < 0.0001 indicates significant differences). Error bars represent median with 95% confidence intervals. For detailed statistical analysis, refer to tables S4 and S5.