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. 2020 Sep 29;370(6520):eabd4250. doi: 10.1126/science.abd4250

Fig. 3. IgG and IgA recognition of immunodominant regions in SARS-CoV-2 spike and nucleoprotein.

Fig. 3

(A) Example response to S and N proteins from a single COVID-19 patient. The y axis indicates the strength of enrichment (z-score; see Materials and methods) of each 56-mer (blue) or 20-mer (red) peptide recognized by the IgG antibodies present in the serum sample. (B) Common responses to S and N proteins across COVID-19 patients. The y axis indicates the fraction of COVID-19 patient samples (n = 348) enriching each 20-mer peptide with either IgG (top) or IgA (bottom) antibodies. (C) Comparison of the IgA and IgG responses in individual COVID-19 patients. Each set of two rows represents the IgG and IgA antibody specificities of a single patient, with data displayed for 10 representative COVID-19 patients. Numeric values indicate the degree of enrichment (z-score) of each peptide tiling across the S and N proteins.