Table 1. Disease-causing variants identified in patients with life-threatening COVID-19.

Gene	Inheritance	Genetic form	Genotype	Gender	Age [years]	Ancestry/residence	Outcome
TLR3	AD	Known	p.Ser339fs/WT	M	40	Spain	Survived
TLR3	AD	Known	p.Pro554Ser/WT	M	68	Italy	Survived
TLR3	AD	Known	p.Trp769*/WT	M	77	Italy	Survived
TLR3	AD	Known	p.Met870Val/WT	M	56	Colombia/Spain	Survived
UNC93B1	AD	New	p.Glu96*/WT	M	48	Venezuela/Spain	Survived
TICAM1	AD	Known	p.Thr4Ile/WT	M	49	Italy	Survived
TICAM1	AD	Known	p.Ser60Cys/WT	F	61	Vietnam/France	Survived
TICAM1	AD	Known	p.Gln392Lys/WT	F	71	Italy	Deceased
TBK1	AD	Known	p.Phe24Ser/WT	F	46	Venezuela/Spain	Survived
TBK1	AD	Known	p.Arg308*/WT	M	17	Turkey	Survived
IRF3	AD	Known	p.Glu49del/WT	F	23	Bolivia/Spain	Survived
IRF3	AD	Known	p.Asn146Lys/WT	F	60	Italy	Survived
IRF7	AR	Known	p.Pro364fs/p.Pro364fs	F	49	Italy/Belgium	Survived
IRF7	AR	Known	p.Met371Val/p.Asp117Asn	M	50	Turkey	Survived
IRF7	AD	New	p.Arg7fs/WT	M	60	Italy	Survived
IRF7	AD	New	p.Gln185*/WT	M	44	France	Survived
IRF7	AD	New	p.Pro246fs/WT	M	41	Spain	Survived
IRF7	AD	New	p.Arg369Gln/WT	M	69	Italy	Survived
IRF7	AD	New	p.Phe95Ser/WT	M	37	Turkey	Survived
IFNAR1	AR	Known	p.Trp73Cys/Trp73Cys	M	38	Turkey	Survived
IFNAR1	AR	Known	p.Ser422Arg/Ser422Arg	M	26	Pakistan/Saudi Arabia	Deceased
IFNAR1	AD	New	p.Pro335del/WT	F	23	China/Italy	Survived
IFNAR2	AD	New	p.Glu140fs/WT	F	54	Belgium	Survived