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. 2021 Jan 4;22(2):e51162. doi: 10.15252/embr.202051162

Figure EV1. Iron transportation signaling is impaired in colorectal cancers.

Figure EV1

  • A, B
    Kaplan–Meier survival curves for patients with colon cancer containing low or high expression of CP (low expression of CP, n = 49 patients; high expression of CP, n = 116 patients) and TFRC (low expression of TFRC, n = 74 patients; high expression of TFRC, n = 91 patients) mRNA in the GSE dataset.
  • C
    RT–qPCR analysis of TFRC mRNA levels in colon tumors and matched adjacent normal tissues (n = 101 human samples, ***P < 0.001, two‐tailed paired Student’s t‐test).
  • D
    The mRNA level of IREB2 in normal (n = 17) or colorectal cancer (n = 16) tissues from the GEO database (GDS4382) (mean ± s.e.m., ns, not significant (P > 0.05), two‐tailed unpaired Student’s t‐test).
  • E
    The relationship of protein level and mRNA level of IREB2 in colon cancer (n = 8 samples, P = 0.4185, two‐tailed Pearson correlation analysis).