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. 2021 Jan 5;22(2):e51524. doi: 10.15252/embr.202051524

Figure 5. REST/NRSF target genes were not enriched at E11.5 in offspring embryonic brains derived from aged fathers.

Figure 5

  1. Volcano plot for DEGs in the embryonic brain of YFO and AFO at E11.5 (n = 3 in each group). Green lines indicate a twofold change and P = 0.01. Orange dots indicate REST/NRSF target genes.
  2. GO gene sets in AFO upregulated genes.
  3. GO gene sets in AFO downregulated genes.
  4. Motif gene sets in AFO upregulated genes.
  5. GSEA plots of DEGs for REST/NRSF target gene sets.
  6. GSEA plots of DEGs for early‐fetal gene sets.
  7. GSEA plots of DEGs for late‐fetal gene sets.
  8. GSEA plots of DEGs for DNA hypo‐methylation neighboring gene sets.
  9. GSEA plots of DEGs for DNA hypo‐methylation neighboring gene sets with REST/NRSF binding motifs.

Data information: Data are presented in the volcano plot or line chart format. *P < 0.05, **P < 0.01, ***P < 0.001, determined by volcano or nominal GSEA P‐value. NES, normalized enrichment score.