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. Author manuscript; available in PMC: 2021 Nov 24.
Published in final edited form as: Chem Mater. 2020 Nov 5;32(22):9508–9530. doi: 10.1021/acs.chemmater.0c03018

Figure 2.

Figure 2.

Scheme of hydrogel biofunctionalization. The osteogenic properties of hydrogels are enhanced by various modifications including bioconjugation, composite formation, and encapsulation of osteogenic components. Bioconjugation enables covalent tethering of numerous functional groups. Composite hydrogel allows non-covalent incorporation of functional organic or inorganic fillers. Moreover, diverse osteogenic components (proteins, cells, genes, small molecules, or bone grafts) can be encapsulated into hydrogel network.