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. Author manuscript; available in PMC: 2021 Nov 24.
Published in final edited form as: Chem Mater. 2020 Nov 5;32(22):9508–9530. doi: 10.1021/acs.chemmater.0c03018

Figure 4.

Figure 4.

Various strategies to improve the osteogenic potentials of hydrogels, a) Tough hydrogel. Double-crosslinked (physical and chemical) regenerated silk fibroin/gelatin (RSF/G) hydrogel with enhanced mechanical properties (AS: ammonium sulfate, EAS: enzyme-treated AS). Adapted with permission from 164. Copyright 2019 Wiley-VCH. b) Self-healing hydrogel. Silk fibroin-calcium phosphate-HA hydrogel and its self-healing property. Adapted with permission from 165. Copyright 2017 Wiley-VCH. c) Porous hydrogel. Lysozyme conjugated hydrogel with tunable degradation to generate porous hydrogel. Adapted with permission from 166. Copyright 2018 American Chemical Society, d) Magnetic-responsive hydrogel. HA hydrogel incorporating FesCE nanoparticles and its heat generation under magnetic stimulus. Adapted with permission from 167. Copyright 2019 American Chemical Society, e) pH-responsive hydrogel. Carboxymethyl chitosan (CMCh)-amorphous calcium phosphate (ACP) hybrid hydrogel demonstrating pH triggered self-assembly. Adapted with permission from 168. Copyright 2019 American Chemical Society.