FIG 2.

Mycobiome diversity and composition. (A) Relative abundance of Penicillium OTU14 which was significantly different between responders and nonresponders at baseline. Testing was performed using LEfSe (LDA score, 3.68; P < 0.05). (B) Species richness (d) at baseline (P-W0) and week 1 of FMT (P-W1) for responders (-Resp) and nonresponders (-Non). Significance was tested using Welch’s t test for each of the two comparisons reported. (C) Coexclusion relationships between Candida OTU2 with similarity to Candida albicans and two bacterial taxa (OTU18 and OTU34). Nonparametric relationships were identified using the MINE framework. OTU18 was classified to Dorea, and OTU34 was classified to Clostridium XVIII. (D) Heatmaps of mean relative abundances of bacterial OTU18 and OTU34 across responders’ baseline and post-FMT samples as well as donor samples.