Table 4. New-onset metabolic features and cardiovascular events (with n, % and age-sex adjusted risk ratios) after 7-years (2014) among controls and those excluded by NAFLD and MAFLD definitions.

Outcomes in 2014	Controls N* = 255	Excluded by NAFLD definition but captured by MAFLD definition N* = 57	Adjusted RR (95% confidence intervals) for NAFLD vs controls, p value	Excluded by MAFLD definition but captured by NAFLD definition N* = 30	Adjusted RR (95% confidence intervals) for MAFLD vs controls, p value
Incident general obesity	9/254 (3.5%)	5/22 (22.7%)	4.3 (1.5–12.2) 0.006	1/24 (4.2%)	1.1 (1.4–9.5) 0.900
Incident central obesity	39/246 (15.9%)	11/15 (73.3%)	8.8 (4.7–16.2) <0.001	4/23 (17.4%)	1.3 (0.6–3.2) 0.509
Incident DM	31/243 (12.8%)	21/47 (44.7%)	3.8 (2.2–6.5) <0.001	8/27 (29.6%)	2.2 (1.1–4.4) 0.019
Incident HTN	36/218 (16.5%)	8/27 (29.6%)	1.7 (0.9–3.4) 0.114	6/24 (25.0%)	1.4 (0.7–2.9) 0.350
Incident TG	68/231 (29.4%)	11/31 (35.5%)	1.2 (0.7–2.0) 0.568	3/20 (15.0%)	0.5 (0.2–1.5) 0.207
Incident low HDL	68/208 (32.7%)	10/49 (20.4%)	1.7 (0.9–3.2) 0.132	6/23 (26.1%)	1.0 (0.5–1.7) 0.936
CVD non-fatal and fatal events	4/253 (1.6%)	8/48 (14.3%)	7.2 (2.4–21.5) <0.001	1/29 (3.4%)	1.9 (0.25–14.8) 0.531

N*—Number in the original 2007 cohort irrespective of presence or absence of relevant baseline condition. Individuals with existing condition at baseline were excluded in the calculation of risk ratios.