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. 2021 Jan 22;15(1):e0009112. doi: 10.1371/journal.pntd.0009112

Table 3. The transmission elimination probability evaluated by fully age-structured stochastic individual-based simulations of hookworm (with adult worm and eggs/larvae mortality rates set to μ1 = 0.5 and μ2 = 26.0 per year, respectively and the density dependent fecundity factor is set to γ = 0.01, as considered in Ref [17]) with two different clustered community types specified by the TUMIKIA transmission parameters inferred from the baseline epidemiological data in Ref [17].

The parameters quoted are the endemic prevalence P, parasite aggregation parameter k, basic reproduction number R0 and cluster population number N, where the age profiles are all assumed to be exactly flat for simplicity. The transmission elimination probabilities are evaluated after 100 years post-cessation of MDA and are quoted assuming either past behaviour-independent adherence (i.e., simple time-dependent coverage in age groups and only population heterogeneity at the level of age bins) or the adherence behaviour inferred from our model in this paper for the TUMIKIA project (see S2 Appendix). In parameter set 1: (P, k, R0, N) = (0.15, 0.05, 2.1, 1000) and parameter set 2: (P, k, R0, N) = (0.4, 0.15, 2.5, 1000).

Community type (see Ref [17]) Transmission elimination probability (Past independent adherence) Transmission elimination probability (TUMIKIA adherence)
1: Lower baseline prevalence, less intense transmission but higher aggregation. 0.582 0.148
2: Higher baseline prevalence, more intense transmission but lower aggregation. 0.902 0.672