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. 2021 Jan 22;17(1):e1008499. doi: 10.1371/journal.pcbi.1008499

Fig 8. Different scenarios of hidden hearing loss have additive effects on SGN activity.

Fig 8

(A) Sound-evoked CAPs of SGN fiber populations with different myelinopathy and synaptopathy scenarios at 70dB SPL, averaged over 50 simulations (dashed lines correspond to the peaks of each CAP, labeled with the same colors as the CAPs). Combined synaptopathy and myelinopathy (Case 3) showed additive effects on the decrease in CAP peak amplitude, but not on the increase in CAP peak latency (compare to Cases 1 and 2). Combined different myelinopathies showed additive effects on both CAP peak amplitude and latency (compare Cases 2 and 4). (B) Comparison of average CAP measures for different myelinopathy and synaptopathy cases relative to normal, and between cases at 70 dB SPL (*p<0.05, **p<0.01, #p<0.001). Normalized CAP amplitudes (C) and CAP latencies (D) for different myelinopathy and synaptopathy cases for various sound levels, averaged over 50 simulations. Shaded areas correspond to the standard error of the mean.