Fig 1.

Pedigree of the family-2 where the index patient and her affected brother were compound heterozygous for c.4371del, p.(Thr1458Glnfs*36) and c.72G>C, p.(Gln24His) in NRAP similarly as her 21-year brother who were on medication initiated before the results of genetic testing were available due to borderline imaging findings suggesting cardiomyopathy. He did not fulfill diagnostic criteria of DCM at the time of the study. DNA was not available from one affected individual who died for DCM at age of 34. All family members who were heterozygous only for the other variant or were homozygous for the wild type allele were unaffected.