Table 1. Baseline clinical characteristics based on final pattern of motor impairments developed during the study.
| Covariates | All (n = 867) | NI (n = 110)‡ | MD (n = 362)‡ | PARK (n = 40)‡ | Park|MD (n = 236)‡ | MD|PARK (n = 119)‡ |
|---|---|---|---|---|---|---|
| Demographics | ||||||
| Age, years, mean (SD) | 75.5 (7.4)** | 74.1 (7.3) | 73.6 (7.5) | 78.7 (6.6) | 76.9 (7.0) | 78.4 (6.5) |
| Female, n (%) | 658 (76) | 76 (69) | 281 (78) | 27 (68) | 189 (80) | 85 (71) |
| Education, years, mean (SD) | 16.5 (3.5)* | 17.1 (3.6) | 16.6 (3.4) | 15.7 (3.3) | 16.4 (3.5) | 15.7 (3.4) |
| Chronic health conditions | ||||||
| Vascular risk factors and diseases | ||||||
| Hypertension, n (%) | 403 (47) | 52 (47) | 166 (46) | 20 (50) | 113 (48) | 52 (44) |
| Diabetes, n (%) | 87 (10)* | 10 (9) | 38 (11) | 10 (25) | 16 (7) | 13 (11) |
| History of smoking, n (%) | 297 (34) | 41 (37) | 128 (35) | 13 (33) | 77 (33) | 38 (32) |
| Number of 3 vascular risk factors, mean (SD) | 0.9 (0.8) | 0.9 (0.8) | 0.9 (0.8) | 1.1 (0.9) | 0.9 (0.8) | 0.9 (0.8) |
| History of stroke, n (%) | 43 (5) | 5 (5) | 16 (5) | 2 (5) | 13 (6) | 7 (6) |
| History of myocardial infarction, n (%) | 63 (7) | 6 (5) | 26 (7) | 5 (13) | 16 (7) | 10 (8) |
| History of claudication, n (%) | 40 (5) | 1 (1) | 18 (5) | 1 (3) | 15 (6) | 5 (4) |
| Number of 3 vascular diseases, mean (SD) | 0.2 (0.4) | 0.1 (0.3) | 0.2 (0.4) | 0.2 (0.4) | 0.2 (0.4) | 0.2 (0.5) |
| Musculoskeletal pain (any joint), n (%) | 331 (38) | 33 (30) | 133 (37) | 13 (33) | 107 (45) | 45 (38) |
‡NI: Remained without mobility impairment and parkinsonism during the study; MD: Developed only mobility disability; PARK: Developed only parkinsonism; PARK|MD: Developed parkinsonism following mobility disability; MD|PARK: Developed mobility disability following parkinsonism.
** P< 0.001.
* P< 0.05.