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. 2021 Feb 3;7(6):eabd9307. doi: 10.1126/sciadv.abd9307

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Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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Fig. 9 — (A) ADE-enabled nanoscale automated electrophile synthesis based on the U-4CR of isocyanide building block 22. (B) Heat plot of 192 compounds based on mass spectrometry analysis: green for major product formation, yellow for medium product formation, blue for no product formation, and white for Echo reagent transfer failure. (C) Exemplary amine and carboxylic acid building blocks used. (D) Exemplary product structures of the first two columns A and B. (E) Structures of resynthesized compounds on a millimole scale (red-boxed in heat plot).