Table 1. Final multivariable Cox PH model with selected clinical variables, CNA Quartiles and interactions.
| Clinical Variable | Beta | SE | HR | 95% CI | P-value | Significance |
|---|---|---|---|---|---|---|
| PAM50: | ||||||
| Luminal A (Ref) | - | - | - | - | - | - |
| Luminal B | 1.069 | 0.299 | 2.912 | (1.619—5.237) | <0.001 | *** |
| Histological Grade: | ||||||
| 1 (Ref) | - | - | - | - | - | - |
| 2 | 0.381 | 0.254 | 1.464 | (0.889—2.410) | 0.134 | |
| 3 | 0.528 | 0.262 | 1.696 | (1.014—2.837) | 0.044 | * |
| Tumour Size | 0.015 | 0.003 | 1.015 | (1.010—1.020) | <0.001 | *** |
| Positive Lymph Nodes | 0.050 | 0.008 | 1.051 | (1.034—1.069) | <0.001 | *** |
| Age at Diagnosis | 0.018 | 0.005 | 1.018 | (1.008—1.029) | <0.001 | *** |
| HER2 Status: | ||||||
| Negative (Ref) | - | - | - | - | - | - |
| Positive | 0.541 | 0.202 | 1.717 | (1.157—2.550) | 0.007 | ** |
| CNA Quartile: | ||||||
| CNA Q1 (Ref) | - | - | - | - | - | - |
| CNA Q2 | 0.315 | 0.256 | 1.370 | (0.829—2.265) | 0.219 | |
| CNA Q3 | 0.767 | 0.247 | 2.152 | (1.326—3.493) | 0.002 | ** |
| CNA Q4 | 0.839 | 0.272 | 2.315 | (1.360—3.942) | 0.002 | ** |
| CNA Quartile by PAM50: | ||||||
| CNA Q2:LumB | -0.764 | 0.395 | 0.466 | (0.215—1.010) | 0.053 | . |
| CNA Q3:LumB | -0.730 | 0.364 | 0.482 | (0.236—0.983) | 0.045 | * |
| CNA Q4:LumB | -0.909 | 0.370 | 0.403 | (0.195—0.831) | 0.014 | * |
| Likelihood Ratio Test p-value | <2e-16 | *** | ||||
| Wald Test p-value | <2e-16 | *** | ||||
| Score (logrank) Test p-value | <2e-16 | *** |
Signifcance codes: 0(***) 0.001(**) 0.01(*) 0.05(.) 0.1()
SE: Standard Error; HR: Hazard Ratio; CI: Confidence Interval